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The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular morpho genesis, despite the enormous growth of interest that occurred nationally and inter nationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or multi authored volumes, without a specific theme. What is missing are the unifying concepts that can often make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardiovascular mor not only as an important archival and didactic reference phogenesis that will serve source for those who have recently come into the field but also as a guide to the evo lution of a field that is clearly coming of age.
Part 1: Vascular Morphogenesis in the Mammary Gland// Chapter 1:Vascular morphogenesis in the mammary gland - Introduction and overview. M. Luisa Iruela-Arispe, Maria Asuncion Ortega, Sarah Oikemus, and Michael S. Pepper Chapter 2: Growth factor regulation of physiological angiogenesis in the mammary gland. Anne Saaristo, Marika J. Karkkainen, Kari Alitalo, Roberto Montesano, Luisa Iruela-Arispe, and Michael S. Pepper Chapter 3: The role of angiogenesis in breast cancer progression. Sandra W. McLeskey and Robert B. Dickson Chapter 4: Angiogenesis in mammary tumors: Quantitation and relation to prognosis. Stephen B. Fox Chapter 5: Oncogenes, anti-oncogenes and genetic regulators of vascular development. Timothy F. Lane and Alicia Collado-Hidalgo// Part 2: Vascular Morphogenesis in the Ovary//Chapter 6: Vascular morphogenesis in the ovary - Introduction and overview. Hellmut G. Augustin Chapter 7: Growth factors during ovarian angiogenesis. Anna T. Grazul-Bilska, Dale A. Redmer, and Lawrence P. Reynolds Chapter 8: Vascular endothelial cell growth factor: A key regulator of physiological angiogenesis. Napoleone Ferrara Chapter 9: Hormonal regulation of gonadal angiogenesis. H. William Schnaper and Constance E. Runyan Chapter 10: Angiogenesis, vascular imaging, and therapeutic approaches in ovarian tumors. Elise C. Kohn and Steven K. Libutti// Part 3: Vascular Morphogenesis in the Uterus// Chapter 11: The vascular system in the endometrium - Introduction and overview. Peter A. W. Rogers and Caroline E. Gargett Chapter 12: The clinical relevance of uterine vascular growth, remodelling and repair. Martha Hickey and Ian S. Fraser Chapter 13: Angiogenesis in endometriosis. Michael D. Mueller and Robert N. Taylor// Part 4: Vascular Morphogenesis in the Placenta// Chapter 14: Placental vascular morphogenesis - Introduction and overview. D. Stephen Charnock-Jones and Stephen K. Smith Chapter 15: Placental functional morphology. Graham J. Burton Chapter16: Placenta Growth Factor (PlGF). M. Graziella Persico Chapter 17: Early placental vascular morphogenesis. Caroline H. Damsky and Susan J. Fisher