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Myofibrillogenesis has been studied extensively over the last 100
years. Until recently, we have not had a comprehensive understanding
of this fundamental process. The emergence of new technologies in
molecular and cellular biology, combined with classical embryology,
have started to unravel some of the complexities of myofibril assembly
in striated muscles.
In striated muscles, the contractile proteins are arranged in a highly
ordered three dimensional lattice known as the sarcomere. The assembly
of a myofibril involves the precise ordering of several proteins into
a linear array of sarcomeres. Multiple isoforms in many of these
proteins further complicate the process, making it difficult to define
the precise role of each component. This volume has been compiled as a
comprehensive reference on myofibrillogenesis.
In addition, the book includes reviews on myofibrillar disarray under
various pathological conditions, such as familial hypertrophic
cardiomyopathy (FHC), and incorporates a section on the conduction
system in the heart. Much of the information in this volume has not
been described elsewhere. Presented in a manner to be of value to
students and teachers alike, "Myofibrillogenesis" will be an
invaluable reference source for all in the fields of muscle biology
and heart development.
Content Level »Research
Keywords »biology - cell - development - embryology - gene - gene expression - heart - phenotype - protein - proteins - regulation - signal transduction - system
Foreword - Roger R. Markwald * Preface * Section I: Assembly of myofibrillar proteins in striated muscle * 1. Myofibrillogenesis in cardiac muscle - Joseph W. Sanger and Jean M. Sanger * 2. Dynamics of contractile proteins constituting myofibrils in living muscle cells - Yutaka Shimada, Tin Moe Nwe, Fukuko Hasebe-Kishi, and Homare Suzuki * 3. Emergence of the first myofibrils and targeting mechanisms directing sarcomere assembly in developing cardiomyocytes - Elisabeth Ehler and Jean-Claude Perriard * 4. Tropomodulin: An important player in cardiac myofibrillogenesis - Catherine McLellan and Carol C. Gregorio * Section II: Maintenance and manipulation of myofibrillar organization * 5. Maintaining the fully differentiated cardiac sarcomere - Daniel E. Michele and Joseph M. Metzger * 6. Manipulation of myofibrillogenesis in whole embryonic hearts - Robert W. Zajdel, Matthew D. McLean, Syamalima Dube, Larry F. Lemanski, and Dipak K. Dube * Section III: Regulation of expression of myofibrillar proteins * 7. Molecular regulation of cardiac myofibrillogenesis: Roles of serum response factor, Nkx2-5 and GATA-4 - Robert J. Schwartz, Jorge Sepulveda and Naraswathamy S. Belaguli * 8. Regulation and organization of human troponin genes' - Paul J. R. Barton, Kimberley A. Dellow, Pankaj K. Bhavsar, Martin E. Cullen, Antony J. Mullen, and Nigel J. Brand * 9. Signal transduction in myofibrillogenesis, cell growth and hypertrophy - Michael Wagner, Saiyid Shafiq, Eduardo Mascareno and M. A. Q. Siddiqui * 10. Cytoskeletal gene expression in the developing cardiac conduction system - Robert Welikson and Takashi Mikawa * Section IV: Heart development and myofibrillar organization * 11. Onset of a cardiac phenotype in the early embryo - Carol A. Eisenberg and L. M. Eisenberg * 12. Cellular, molecular and developmental studies on heart development in normal and cardiac mutant axolotls, Ambystoma mexicanum - Larry F. Lemanski, Xupei Huang, R. W. Zajdel, Sharon L. Lemanski, Chi Zhang,Fanyin Meng, Dalton Foster, Qing Li, and Dipak K. Dube * Section V : Cardiomyopathy and myofibrillar organization * 13. The function of normal and familial hypertrophic cardiomyopathy - associated tropomyosin - Rethinasamy Prabhakar, Kathy Pieples, Ganapathy Jagatheesan, Stephanie Burge and David F. Wieczorek * 14. Cardiomyopathies and myofibril abnormalities - Jeffrey A. Towbin and Meil E. Bowies * Index