Overview
- Editors:
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D. Lansing Taylor
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Cellumen, Inc., Pittsburgh
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Jeffrey R. Haskins
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Cellomics, Inc., Pittsburgh
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Kenneth A. Giuliano
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Cellumen, Inc., Pittsburgh
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Table of contents (31 protocols)
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Reagents
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- Michael J. Ignatius, Jeffrey T. Hung
Pages 233-244
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- K. Gregory Moore, Wayne Speckmann, Ronald P. Herzig
Pages 245-251
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- Peter G. Conrad II, Rajesh V. Chavli, Richard S. Givens
Pages 253-265
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Informatics and Bioinformatics
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Front Matter
Pages 267-267
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- R. Terry Dunlay, Wallace J. Czekalski, Mark A. Collins
Pages 269-280
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- Sean Ekins, Yuri Nikolsky, Andrej Bugrim, Eugene Kirillov, Tatiana Nikolskaya
Pages 319-350
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Assays and Applications of High Content Screening
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Front Matter
Pages 351-351
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- Jackie L. Stilwell, Yinghui Guan, Richard M. Neve, Joe W. Gray
Pages 353-365
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- Andreas Vogt, John S. Lazo
Pages 389-400
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- Frosty Loechel, Sara Bjørn, Viggo Linde, Morten Præstegaard, Len Pagliaro
Pages 401-414
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- Peter O’Brien, Jeffrey R. Haskins
Pages 415-425
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- John B. Kerrison, Donald J. Zack
Pages 427-434
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Back Matter
Pages 435-444
About this book
There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences. Academic research has been primarily focused on hypothesis-driven research. However, the success of the human genome project, a discovery-driven research approach, has opened the door to adding other types of discovery-driven research to a continuum of research approaches. In contrast, drug discovery research in the pharmaceutical industry has embraced discovery-driven research for many years. A good example has been the discovery of active compounds from large chemical libraries, through screening campaigns. The success of the human genome project has also demonstrated the need for both academic researchers and industrial researchers to now understand the functions of genes and gene products. The cell is the basic unit of life and it has been at the cellular level where function can be demonstrated most cost-effectively and rapidly. High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell.
Reviews
"...very useful." -Weighted Numberical Score: 97 - 5 Stars!-Doody's Health Science Book Review Journal