Overview
- Editors:
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Wolfgang Walther
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Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Ulrike Stein
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Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Table of contents (39 protocols)
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Experimental Approaces To Cancer Gene Therapy
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- Yu-An Zhang, John Nemunaitis, Alex W. Tong
Pages 261-271
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Experimental Approaces To Cancer Gene Therapy
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- Wolfgang Uckert, Lene Pedersen, Walter Günzburg
Pages 275-285
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- Ulrich Herrlinger, Andreas Jacobs, Manish Aghi, Deborah E. Schuback, Xandra O. Breakefield
Pages 287-312
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- Alexander L. Rakhmilevich, Ning-Sun Yang
Pages 331-344
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- Shotaro Tsuruta, Akio Ido, Shigenobu Nagataki
Pages 345-359
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- Wolfgang Walther, Ulrike Stein, Robert H. Shoemaker, Peter M. Schlag
Pages 371-392
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Experimental Approaces To Cancer Gene Therapy
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- Ramon Alemany, Wei-Wei Zhang
Pages 395-412
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- Mary E. Fox, Marilyn J. Lemmon, Amato J. Giaccia, Nigel P. Minton, J. Martin Brown
Pages 413-418
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- David Bermudes, Brooks Low, John M. Pawelek
Pages 419-436
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Clinical Protocols for Cancer Gene Therapy
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Front Matter
Pages 437-616
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- Evanthia Galanis, Joseph Rubin
Pages 453-467
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- Uwe Trefzer, Guido Weingart, Wolfram Sterry, Peter Walden
Pages 469-475
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Clinical Protocols for Cancer Gene Therapy
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Front Matter
Pages 437-616
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- Rajagopal Ramesh, Anupama Munshi, Aizen J. Marrogi, Scott M. Freeman
Pages 479-498
About this book
Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.
Reviews
"A wide variety of methods used to deliver genes to tumors are discussed, as are the type of genes used. This includes tumor vaccination, suicide genes, antisense genes, ribozymes, etc. The unique aspect of this book is the translational approach of explaining laboratory techniques as well as the application to patients. . .This book is well written and a translational resource for those interested in the rapidly advancing and novel field of gene therapy for malignancies."-Doody's Health Science Book Review Journal