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Experimental Models of Chronic Inflammatory Diseases

  • Conference proceedings
  • © 1977

Overview

Editors:
  1. Leonard Eleazar Glynn

    1. The Mathilda and Terence Kennedy Institute of Rheumatology, Hammersmith, London, Great Britain

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  2. Horst Dieter Schlumberger

    1. Bayer Pharma-Forschungszentrum, Institut für Immunologie und Onkologie, Wuppertal 1, Fed. Rep. of Germany

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Part of the book series: Bayer-Symposium (BAYER-SYMP, volume 6)

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Table of contents (33 papers)

  1. Front Matter

    Pages I-XIII
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  2. Welcome

    1. Welcome

      • H. D. Schlumberger
      Pages 1-2

  3. Experimental Models of Rheumatoid Lesions

    1. Front Matter

      Pages 3-3
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    2. Experimental Models of Rheumatoid Inflammation

      • D. C. Dumonde, Elizabeth H. Jones, R. H. Kelly, Carolyn M. Oates
      Pages 4-27

    3. Persistence of Antigen in Experimental Allergic Monoarthritis

      • H. E. Jasin, T. D. Cooke
      Pages 28-32

    4. Experimental Subcutaneous Granulomata Simulating R. A. Nodules

      • L. E. Glynn
      Pages 33-34

    5. Studies on the Mitotic Responsiveness of “T” Cells After Stimulation with Contact Sensitizing Agents

      • A. J. S. Davies, V. J. Wallis, E. Leuchars, I. Gery, T. Palmer
      Pages 35-40

    6. Rheumatoid-Type Lymph Node Changes in Animals Exhibiting Immunoregulatory Defects

      • R. H. Kelly
      Pages 41-50

  4. Experimental Models of Systemic Lupus

    1. Front Matter

      Pages 51-51
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    2. Autoimmunity: A Problem of Disordered Immunologic Regulation

      • N. Talal, J. R. Roubinian, R. Papoian, R. J. Pillarisetty
      Pages 52-58

    3. Chronic Infections of C-Type RNA Viruses

      • Natalie M. Teich, R. A. Weiss
      Pages 59-70

    4. Evidence for a Virus in Canine Systemic Lupus Erythematosus

      • R. M. Lewis
      Pages 71-76

    5. Viral Replication in Lymphocytes and the Pathogenesis of Connective Tissue Diseases

      • A. M. Denman, D. J. Appleford, R. C. Imrie, M. J. Kinsley, B. K. Pelton, T. Schnitzer
      Pages 77-92

  5. Recent Approaches to Experimental Immune Complex Disease and Allergic Vasculitis

    1. Front Matter

      Pages 93-93
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    2. Immune Complex Diseases: Cellular Mediators and the Pathogenesis of Inflammatory Tissue Injury Produced by Immune Complexes

      • P. M. Henson
      Pages 94-106

    3. Antibody Affinity, Macrophage Function and Immunoregulation in Murine Immune Complex Disease

      • M. W. Steward
      Pages 107-116

    4. Features of Human Spontaneous Vasculitis Reproduced Experimentally in Animals. Effects of Antiglobulins, C-Reactive Protein and Fibrin

      • W. E. Parish
      Pages 117-151

    5. Mechanisms Involved in Clinical Allergic Vasculitis

      • J. J. Cream
      Pages 152-163

    6. Significance of Anti-IgG Antibodies in Experimental Arthritis

      • K. Fehr, M. Velvart, A. Böni
      Pages 164-181

    7. Immune Complex Arthritis - In Man and Experimental Animals

      • G. Loewi
      Pages 182-186
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Keywords

About this book

With the introduction of antibiotics acute inflammatory disease has ceased to be the dominant problem in general medical practice and its place is now increasingly occupied by chronic inflamma­ tory disease of which the rheumatic diseases constitute the most important group. lwo aspects of these diseases need to be consid­ ered, their aetiology and their pathogenesis. In some respects the latter is more important since even when the aetiology is known, as for example the haemolytic streptococcus in rheumatic fever, the mechanism by which the infecting agent accomplishes the development of the lesions that characterise the disease are still largely unknown. Still more so is this the case in rheuma­ toid arthritis and other chronic inflammations where the aetio­ logical agents are unknown. In an attempt to clarify the pathogenic mechanisms involved, sev­ eral attempts have been made to induce comparable lesions in ex­ perimental animals, partly to test underlying hypotheses, and partly to provide test situations for the trial of new therapeu­ tic agents. In view of the deficiencies in the current drug treat­ ment of chronic inflammatory disease there are many who feel that this is largely due to the inadequacy of the models avail­ able for test purposes.

Editors and Affiliations

  • The Mathilda and Terence Kennedy Institute of Rheumatology, Hammersmith, London, Great Britain

    Leonard Eleazar Glynn

  • Bayer Pharma-Forschungszentrum, Institut für Immunologie und Onkologie, Wuppertal 1, Fed. Rep. of Germany

    Horst Dieter Schlumberger

Bibliographic Information

  • Book Title: Experimental Models of Chronic Inflammatory Diseases

  • Editors: Leonard Eleazar Glynn, Horst Dieter Schlumberger

  • Series Title: Bayer-Symposium

  • DOI: https://doi.org/10.1007/978-3-642-66573-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1977

  • Softcover ISBN: 978-3-642-66575-2Published: 17 November 2011

  • eBook ISBN: 978-3-642-66573-8Published: 06 December 2012

  • Series ISSN: 0067-4672

  • Edition Number: 1

  • Number of Pages: XIV, 462

  • Topics: Rheumatology, Immunology, Pathology

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