Overview
- Editors:
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Sukriti Nag
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Banting Institute, Dept. Laboratory Med. & Pathobiology, University of Toronto, Toronto, Canada
- Reviews the relevant aspects of brain biology then delves into in-depth, practical laboratory protocols Explores beyond the blood-brain barrier into other vital neural barriers Features tips for completing the protocols successfully, relayed by the expert contributors from their wealth of experience
- Includes supplementary material: sn.pub/extras
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Table of contents (25 protocols)
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Models to Study the Barriers
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Front Matter
Pages 355-355
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- Robert L. Pinsonneault, Nasima Mayer, Fahima Mayer, Nebiyu Tegegn, Roland J. Bainton
Pages 357-369
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- Brian P. Eliceiri, Ana Maria Gonzalez, Andrew Baird
Pages 371-378
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- Gokulan Thanabalasundaram, Jehad El-Gindi, Mira Lischper, Hans-Joachim Galla
Pages 379-399
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- Robin D. Hamilton, Lopa Leach
Pages 401-416
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- Yasuteru Sano, Takashi Kanda
Pages 417-425
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Delivery of Therapeutic Agents Across the Barriers
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Front Matter
Pages 427-427
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- Marie Blanchette, David Fortin
Pages 447-463
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- Umar Iqbal, Abedelnasser Abulrob, Danica B. Stanimirovic
Pages 465-481
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- Andrew Baird, Brian P. Eliceiri, Ana Maria Gonzalez, Conrad E. Johanson, Wendy Leadbeater, Edward G. Stopa
Pages 483-498
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Back Matter
Pages 499-502
About this book
Evolving technologies starting with tracer studies, and more recently with genomics and proteomics, have provided novel information about the molecular properties of cerebral endothelium and astrocytes; however, further studies must be done in animal models of neurological diseases and in humans to get a clearer understanding of the pathogenesis of blood-brain barrier (BBB) breakdown in nervous system diseases. In The Blood-Brain and Other Neural Barriers: Reviews and Protocols, experts in the field present a series of cutting-edge protocols which can be used to study the barriers. Opening with detailed information on components of the neurovascular unit as well as the blood-cerebrospinal, blood-retinal, and blood-nerve barriers, the book continues with meticulous techniques to image the barriers in humans and experimental animals, followed by cutting-edge molecular techniques to study the BBB and novel models to study the barriers, and it concludes with techniques for the delivery of therapeutic agents across the BBB. Written in the highly successful Methods in Molecular Biologyâ„¢ series format, protocol chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, The Blood-Brain and Other Neural Barriers: Reviews and Protocols will aid the research efforts of not only graduate students but also more experienced investigators and support future studies of these vital systems.
Editors and Affiliations
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Banting Institute, Dept. Laboratory Med. & Pathobiology, University of Toronto, Toronto, Canada
Sukriti Nag