Overview
- Editors:
-
-
Vinagolu K. Rajasekhar
-
Memorial Sloan-Kettering Cancer Center, New York, USA
-
Mohan C. Vemuri
-
Invitrogen Corporation, Frederick, USA
- Incorporates all essential and relevant information in the study of stem cells
- Excellently presented data by leading experts in the field of stem cells
- Includes supplementary material: sn.pub/extras
Access this book
Other ways to access
Table of contents (43 chapters)
-
Regulation by Stem Cell Niches
-
- Suzanne M. Watt, Grigorios Tsaknakis, Sinead P. Forde, Lee Carpenter
Pages 211-231
-
Epigenetic Mechanisms in Stem Cells
-
Front Matter
Pages 233-233
-
- Joyce E. Ohm, Stephen B. Baylin
Pages 235-246
-
- Monther Abu-Remaileh, Yehudit Bergman
Pages 247-256
-
- Philippe Collas, Sanna Timoskainen, Agate Noer
Pages 257-268
-
- Bhaskar Thyagarajan, Mahendra Rao
Pages 269-276
-
-
-
Signaling and Regulation in Select Stem Cell Types
-
Front Matter
Pages 291-291
-
- D. Reynolds, Ludovic Vallier, Zhenzhi Chng, Roger Pedersen
Pages 293-308
-
- Tohru Kimura, Toru Nakano
Pages 309-318
-
- Daylon James, Marco Seandel, Shahin Rafii
Pages 319-328
-
- Vivek M. Tanavde, Lailing Liew, Jiahao Lim, Felicia Ng
Pages 329-335
-
-
-
- Takashi Yokoo, Akira Fukui, Kei Matsumoto, Tetsuya Kawamura
Pages 379-390
-
- Caroline E. Gargett, Kjiana E. Schwab
Pages 391-404
-
- Chew-Li Soh, Joanna M.C. Lim, Richard L. Boyd, Ann P. Chidgey
Pages 405-437
-
- Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Naoya Kobayashi
Pages 439-469
-
Disease Paradigms and Stem Cell Therapeutics
-
Front Matter
Pages 471-471
About this book
Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals ofdevelopmental biology.
Reviews
From the reviews:
“This volume is an initial attempt to decipher the key factors involved in stem cell pluripotency, maintenance, and directed differentiation toward specific cell lineages and stem cell types. The presentation of the contents is such that upper-grade undergraduates, graduate students, postgraduates, and basic research as well as clinical research scientists are provided with accessible information about recent advances in the stem cell field. The volume consists of 43 comprehensively written chapters divided into five parts … .” (Anticancer Research, Vol. 29 (11), November, 2009)
Editors and Affiliations
-
Memorial Sloan-Kettering Cancer Center, New York, USA
Vinagolu K. Rajasekhar
-
Invitrogen Corporation, Frederick, USA
Mohan C. Vemuri