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Transforming Growth Factor-Beta in Cancer Therapy, Volume II

Cancer Treatment and Therapy

  • Book
  • © 2008

Overview

Editors:
  1. Sonia B. Jakowlew

    1. Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

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  • Details the role of TGF- ß in cancer treatment and therapy, including its role in development and progression of several different cancers
  • Conveniently divided into three easy-to-follow parts
  • Companion volume details the role of TGF- ß on basic and clinical biology

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (46 chapters)

  1. Development of Inhibitors of Transforming Growth Factor-β Signaling for Therapy

    1. Targeting Transforming Growth Factor-β in Metastasis: In Vitro and In Vivo Mechanisms

      • Michael Reiss
      Pages 609-634

    2. Targeted Downregulation of TGF-β2 with AP 12009 in Tumor Therapy

      • Karl-Hermann Schlingensiepen, Piotr Jachimczak, Birgit Fischer-Blass, Dagmar Fischer, Heike Specht, Susanne Schmaus et al.
      Pages 635-651

    3. Modulating TGF-β Receptor Signaling: A Novel Approach of Cancer Therapy

      • Ulrike Naumann, Michael Weller
      Pages 653-669

    4. Engineering TGF-β Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-β Action

      • Gregory De Crescenzo, Heman Chao, John Zwaagstra, Yves Durocher, Maureen D. O’Connor-McCourt
      Pages 671-684

    5. The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology

      • Leona E. Ling, Juswinder Singh, Claudio E. Chuaqui, P. Ann Boriack-Sjodin, Michael J. Corbley, Doreen J. Lepage et al.
      Pages 685-696

    6. Soluble Type II Transforming Growth Factor-β Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity

      • Eiji Suzuki, Steven M. Albelda
      Pages 697-706

    7. Reversal of EMT by Small-Molecule Inhibitors of TGF-β Type I and II Receptors: Implications for Carcinoma Treatment

      • Markus D. Lacher, W. Michael Korn, Rosemary J. Akhurst
      Pages 707-722

    8. Soluble TGF-β Type III Receptor Suppresses Malignant Progression of Human Cancer Cells

      • Abhik Bandyopadhyay, LuZhe Sun
      Pages 723-735

    9. Targeting Smad-Dependent TGF-β Signaling with Peptide Aptamers

      • F. Michael Hoffmann, Qiqi Cui, S. Kyun Lim, Bryan M. Zhao
      Pages 737-756

    10. Rationale for Anti-TGF-β Antibody Therapy in Oncology

      • Frank J. Hsu, Beverly A. Teicher, John M. McPherson
      Pages 757-774

  2. Back Matter

    Pages 775-786
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Keywords

About this book

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Reviews

From the reviews:

"This volume … provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. … This will likely be of interest to those in the field as well as those who are new … . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. … This will be a great resource for researchers and clinicians … ." (James P Luyendyk, Doody’s Review Service, June, 2008)

Editors and Affiliations

  • Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

    Sonia B. Jakowlew

Bibliographic Information

  • Book Title: Transforming Growth Factor-Beta in Cancer Therapy, Volume II

  • Book Subtitle: Cancer Treatment and Therapy

  • Editors: Sonia B. Jakowlew

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-293-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-715-0Published: 28 February 2008

  • Softcover ISBN: 978-1-61737-736-5Published: 19 November 2010

  • eBook ISBN: 978-1-59745-293-9Published: 01 January 2010

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XXVI, 786

  • Number of Illustrations: 160 b/w illustrations, 4 illustrations in colour

  • Topics: Oncology, Cancer Research, Cell Biology, Pathology

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