Overview
- Editors:
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Etienne-Emile Baulieu
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University of Paris-Sud, Paris, France
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Sheldon J. Segal
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The Rockefeller Foundation, New York, USA
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Table of contents (32 chapters)
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- R. Sitruk-Ware, L. Billaud, I. Mowszowicz, H. Yaneva, P. Mauvais-Jarvis, C. W. Bardin et al.
Pages 243-248
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- M. L. Swahn, S. Cekan, G. Wang, V. Lundstrom, M. Bygdeman
Pages 249-258
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- R. W. Kelly, D. L. Healy, M. J. Cameron, I. T. Cameron, D. T. Baird
Pages 259-262
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- Horacio B. Croxatto, Irving M. Spitz, Ana Maria Salvatierra, C. Wayne Bardin
Pages 263-269
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- Gilbert Schaison, Martine George, Nelly Lestrat, Etienne-Emile Baulieu
Pages 271-278
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- Lynnette K. Nieman, David L. Healy, Irving M. Spitz, George R. Merriam, C. Wayne Bardin, D. Lynn Loriaux et al.
Pages 279-283
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- Donna Shoupe, Daniel R. Mishell Jr., Maria Lacarra, Elia Gutierrez, Pekka Lahteenmaki, Irving M. Spitz
Pages 285-293
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- Paul Robel, Achille Gravanis, Gilbert Schaison, Martine George, Jean de Brux, Pondichery G. Satyaswaroop et al.
Pages 295-306
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- Henri Rochefort, Dany Chalbos
Pages 307-314
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- Irving M. Spitz, Charles E. Wade, Dorothy T. Krieger, Pekka Lahteenmaki, C. Wayne Bardin
Pages 315-329
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- R. C. Gaillard, A. Riondel, A. F. Muller, W. Herrmann, E. E. Baulieu
Pages 331-337
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- Lynnette K. Nieman, George P. Chrousos, Charles Kellner, Irving M. Spitz, Bruce C. Nisula, Gordon B. Cutler Jr. et al.
Pages 339-345
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- Etienne Baulieu, André Ulmann
Pages 347-347
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Back Matter
Pages 349-353
About this book
Advances in basic biological research have proceeded rapidly in recent years. The fields of molecular genetics and immunology have experienced dramatic breakthroughs, capturing the imagination of both the scientific community and the general public. With less public notice, receptor biology has brought a cascade of new discoveries and insights. The entire science of pharmacology has been virtually rewritten in terms of receptor phenomenology. In particular, the discovery of specific receptors for steroid and protein hormones has been of seminal importance. With this new information, we have advanced our understanding of the mechanism and specifity of hormone action. We can now explain how hormones interact selectively with specific target cells and how hormones alter biochemical events within the target cells. These facts have already impacted on applied problems of clinical medicine, particularly in diagnosis and treatment of cancer and some metabolic diseases. Now, a new and important application of basic receptor biology and chemistry looms ahead. Within a few short years since the discovery of the progesterone receptor, chemists have synthesized molecules with a greater affinity for the receptor than progesterone itself and which, while occupying the receptor, fail to trigger the events which transform a target cell from the unstimulated to the stimulated state. This is the basis of the competitive inhibitory action of the anti-progestational agent, synthesized by the chemists at Roussel Uc1af, Paris, and designated RU 486.
Editors and Affiliations
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University of Paris-Sud, Paris, France
Etienne-Emile Baulieu
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The Rockefeller Foundation, New York, USA
Sheldon J. Segal