Overview
- Proceedings from the 5th International Complement Theraputics Conference
- Part of the Aegean Conferences series
- Incorporates cutting-edge research and showcases methods developed and perfected in the last decade
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 735)
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Table of contents (21 chapters)
Keywords
About this book
This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials.
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The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system.Editors and Affiliations
About the editors
Bibliographic Information
Book Title: Complement Therapeutics
Editors: John D. Lambris, V. Michael Holers, Daniel Ricklin
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4614-4118-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-4614-4117-5Published: 19 September 2012
Softcover ISBN: 978-1-4899-7823-3Published: 23 August 2016
eBook ISBN: 978-1-4614-4118-2Published: 19 September 2012
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 320
Topics: Immunology, Microbiology, Infectious Diseases, Pathology