Skip to main content
SpringerLink
Log in

Novel Developments in Stem Cell Mobilization

Focus on CXCR4

  • Book
  • © 2012

Overview

Editors:
  1. Stefan Fruehauf

    1. , Zentrum für Tumordiagnostik und –therapi, Paracelsus-Klinik, Osnabrück, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. W. Jens Zeller

    1. Deutsches Krebsforschungszentrum (G360), Heidelberg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Gary Calandra

    1. Private, Cresco, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A concise review of the current status of knowledge and future developments of CXCR4 will be presented

  • Contributors are internationally leaders in the field

  • A comprehensive treatment of the subject with numerous color illustrations

  • Includes supplementary material: sn.pub/extras

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (24 chapters)

  1. CXCR4 Antagonists for Treatment of Leukemias and Solid Tumors

    1. Application of CXCR4 Inhibitors in Leukemia

      • George Ansstas, Fazia Mir, Michael P. Rettig, Mark Schroeder, Linda Eissenberg, John F. DiPersio
      Pages 335-349

    2. CXCR4 Antagonists for the Treatment of CML

      • Anupriya Agarwal, Thomas O’Hare, Michael Deininger
      Pages 351-367

    3. Targeting CXCR4 in Chronic Lymphocytic Leukemia: Preclinical Rationale and Early Clinical Experience

      • Jan A. Burger
      Pages 369-385

    4. CXCR4-Blockade for Treatment of Breast Cancer

      • Patricia A. Cronin, H. Paul Redmond
      Pages 387-397

    5. Molecular Imaging of CXCR4 Receptor Expression in Tumors

      • Lauren E. Woodard, Sridhar Nimmagadda
      Pages 399-420

  2. Novel Applications

    1. Front Matter

      Pages 421-421
      Download chapter PDF

  3. Novel applications

    1. Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells

      • Sara M. Rankin
      Pages 423-437

    2. Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation

      • Yubin Kang, Nelson J. Chao
      Pages 439-456

    3. Mobilization for Gene Therapy

      • Andre Larochelle, Cynthia E. Dunbar
      Pages 457-485

  4. Back Matter

    Pages 487-496
    Download chapter PDF
Back to top

Keywords

About this book

Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.

Editors and Affiliations

  • , Zentrum für Tumordiagnostik und –therapi, Paracelsus-Klinik, Osnabrück, Germany

    Stefan Fruehauf

  • Deutsches Krebsforschungszentrum (G360), Heidelberg, Germany

    W. Jens Zeller

  • Private, Cresco, USA

    Gary Calandra

Bibliographic Information

  • Book Title: Novel Developments in Stem Cell Mobilization

  • Book Subtitle: Focus on CXCR4

  • Editors: Stefan Fruehauf, W. Jens Zeller, Gary Calandra

  • DOI: https://doi.org/10.1007/978-1-4614-1960-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-1959-4Published: 15 February 2012

  • Softcover ISBN: 978-1-4899-9376-2Published: 12 April 2014

  • eBook ISBN: 978-1-4614-1960-0Published: 15 February 2012

  • Edition Number: 1

  • Number of Pages: XIV, 498

  • Topics: Cancer Research, Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation