Overview
- Editors:
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Andor Szentivanyi
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University of South Florida College of Medicine, Tampa, USA
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Herman Friedman
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University of South Florida College of Medicine, Tampa, USA
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Alois Nowotny
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University of Pennsylvania, Philadelphia, USA
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Table of contents (44 chapters)
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Effects of Endotoxins on Cells of the Immune System
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- Dov H. Pluznik, Stephan E. Mergenhagen
Pages 391-404
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Modulation of the Immune Response by Endotoxins
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Front Matter
Pages 405-405
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- Edgar Ribi, John L. Cantrell, Kuni Takayama, Hans O. Ribi, Kent R. Myers, Nilofer Qureshi
Pages 407-420
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- Kathryn Nixdorff, Sigrid Schell
Pages 421-433
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- Barnet M. Sultzer, John P. Craig, Raymond Castagna
Pages 435-447
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- Stephen A. Stimpson, Ronald E. Esser, William J. Cromartie, John H. Schwab
Pages 449-454
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- G. Pulverer, W. Roszkowski, H. L. Ko, K. Roszkowski, J. Jeljaszewicz
Pages 455-458
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- K. Roszkowski, H. L. Ko, D. van der Waaij, W. Roszkowski, J. Jeljaszewicz, G. Pulverer
Pages 459-463
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- Mauro Bendinelli, Donatella Matteucci, Anna Maria Giangregorio, Pier Giulio Conaldi
Pages 465-478
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- Herman Friedman, Andor Szentivanyi
Pages 479-490
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Back Matter
Pages 503-518
About this book
Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.