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The relevance of neurotrophins in a variety of diseases ranging from inflammatory pain, to neurodegeneration and metabolic disease is comprehensively reviewed
The successful pharmacological avenues used for manipulating neurotrophin signalling in disease as well as future perspectives for their modulation is extensively reviewed
World renowned experts are revealing future perspectives for new therapies based on neurotrophin signalling and their downstream targets
This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.