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Dendritic Cells

  • Book
  • © 2009

Overview

Editors:
  1. Giovanna Lombardi

    1. DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

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  2. Yanira Riffo-Vasquez

    1. 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 188)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Biology of Dendritic Cells

    1. Activation of Dendritic Cells by Toll-Like Receptors and C-Type Lectins

      • Sandra S. Diebold
      Pages 3-30

    2. Dendritic Cell Migration to Peripheral Lymph Nodes

      • Alfonso Martín-Fontecha, Antonio Lanzavecchia, Federica Sallusto
      Pages 31-49

    3. Dendritic Cells in Viral Infections

      • Gabrielle Belz, Adele Mount, Frederick Masson
      Pages 51-77

  3. Role of Dendritic Cells in Disease

    1. Dendritic Cells and their Potential Implication in Pathology and Treatment of Rheumatoid Arthritis

      • M. H. Wenink, W. Han, R. E. M. Toes, T. R. D. J. Radstake
      Pages 81-98

    2. Lung Dendritic Cells: Targets for Therapy in Allergic Disease

      • Bart N. Lambrecht, Hamida Hammad
      Pages 99-114

    3. Dendritic Cells in Rhinitis

      • Alex KleinJan, Bart N. Lambrecht
      Pages 115-136

    4. Role of Epidermal Dendritic Cells in Drug-Induced Cutaneous Adverse Reactions

      • Maria Dolores Ramírez-González, Miguel Herrera-Enríquez, Luisa Geraldine Villanueva-Rodríguez, Andres Eliu Castell-Rodríguez
      Pages 137-162

  4. Manipulation of Dendritic Cells for Immunotherapy

    1. T Cell Regulatory Plasmacytoid Dendritic Cells Expressing Indoleamine 2,3 Dioxygenase

      • David J. Kahler, Andrew L. Mellor
      Pages 165-196

    2. Aspirin and the Induction of Tolerance by Dendritic Cells

      • Matthew Buckland, Giovanna Lombardi
      Pages 197-213

    3. Use of Rapamycin in the Induction of Tolerogenic Dendritic Cells

      • Ryan Fischer, Heth R. Turnquist, Timuçin Taner, Angus W. Thomson
      Pages 215-232

    4. Handbook of Experimental Pharmacology “Dendritic Cells”

      • Cees van Kooten, Annelein S. Stax, Andrea M. Woltman, Kyra A. Gelderman
      Pages 233-249

    5. Induction of Tolerogenic Dendritic Cells by Vitamin D Receptor Agonists

      • Luciano Adorini, Giuseppe Penna
      Pages 251-273

    6. Use of Adenovirus in Vaccines for HIV

      • Steven Patterson, Timos Papagatsias, Adel Benlahrech
      Pages 275-293

    7. IFN-alpha in the Generation of Dendritic Cells for Cancer Immunotherapy

      • Stefano Maria Santini, Caterina Lapenta, Laura Santodonato, Giuseppina D'Agostino, Filippo Belardelli, Maria Ferrantini
      Pages 295-317

    8. Dendritic Cell-Based Immunotherapy in Myeloid Leukaemia: Translating Fundamental Mechanisms into Clinical Applications

      • A. A. van de Loosdrecht, W. van den Ancker, I. Houtenbos, G. J. Ossenkoppele, T. M. Westers
      Pages 319-348

  5. Back Matter

    Pages 349-353
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Keywords

About this book

The understanding of the role of dendritic cells (DCs) in immune responses has come a long way since Steinmann and colleagues described these cells in 1972. - tensive research during the intervening period has provided a good understanding of the complexity of the DC system and its pivotal role in immunity. It is also now clearer how different subsets of DCs interact and regulate each other and how DC populations affect the function of other cells of the immune system. The improved understanding of their role in immune response has led to the idea that modulation of DC functions by, for example, pharmacological agents could be used as a pot- tial therapeutic approach in some pathological conditions. The actual applicability and therapeutic potential of all these approaches is yet to be fully demonstrated but nonetheless, animal models of human diseases are proving to be very helpful in the evaluation of manipulated DCs as a new treatment in diseases like cancer, auto- munity or asthma. DCs are integral to the initiation and regulation of immune response (Banchereau et al. 2000). The outcome of antigen presentation by DCs is determined by their maturation status, which can be induced by their interaction with danger signals. To recognise a wide array of pathogen-associated molecular patterns (PAMP), DCs express a number of pattern recognition receptors (PRR) such as Toll-like rec- tors (TLRs) and C-type lectin receptors (CLR) that recognise structural components of pathogens and discriminate between self and non-self molecules.

Editors and Affiliations

  • DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

    Giovanna Lombardi

  • 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

    Yanira Riffo-Vasquez

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