Springer Theses

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Methodology and Applications

Authors: Hu, Kuan

Free Preview
  • Nominated as an outstanding PhD thesis by Peking University 
  • Reports on important progress in the study of stabilized peptide drugs 
  • Introduces applications in cancer stem cell therapy and self-assembly for novel nanomaterials 
  • Includes a diversity-oriented synthesis methodology for constructing stabilized peptides and a clear study of the correlation between peptides’ structure and their biophysical/biochemical properties
see more benefits

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-981-336-613-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-981-336-612-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. 

Table of contents (4 chapters)

Table of contents (4 chapters)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-981-336-613-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-981-336-612-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Development of In-Tether Carbon Chiral Center-Induced Helical Peptide
Book Subtitle
Methodology and Applications
Authors
Series Title
Springer Theses
Copyright
2021
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-336-613-8
DOI
10.1007/978-981-33-6613-8
Hardcover ISBN
978-981-336-612-1
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XV, 102
Number of Illustrations
10 b/w illustrations, 65 illustrations in colour
Topics