Co-signal Molecules in T Cell Activation
Immune Regulation in Health and Disease
Editors: Azuma, Miyuki, Yagita, Hideo (Eds.)
Free Preview- Explains the basic concepts and roles of co-signal molecules
- Discusses applied and clinical studies using co-stimulation mechanisms
- Presents a variety of potential therapeutic applications
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- About this book
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This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
- About the authors
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Miyuki AzumaTokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, Japan
Hideo YagitaJuntendo University School of Medicine, Dept of Immunology, Japan - Reviews
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- Table of contents (11 chapters)
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Co-signal Molecules in T-Cell Activation
Pages 3-23
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The CD28–B7 Family of Co-signaling Molecules
Pages 25-51
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The TNF–TNFR Family of Co-signal Molecules
Pages 53-84
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Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors
Pages 85-133
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Molecular Dynamics of Co-signal Molecules in T-Cell Activation
Pages 135-152
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Table of contents (11 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Co-signal Molecules in T Cell Activation
- Book Subtitle
- Immune Regulation in Health and Disease
- Editors
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- Miyuki Azuma
- Hideo Yagita
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 1189
- Copyright
- 2019
- Publisher
- Springer Singapore
- Copyright Holder
- Springer Nature Singapore Pte Ltd.
- eBook ISBN
- 978-981-329-717-3
- DOI
- 10.1007/978-981-32-9717-3
- Hardcover ISBN
- 978-981-329-716-6
- Softcover ISBN
- 978-981-329-719-7
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- VI, 326
- Number of Illustrations
- 1 b/w illustrations, 21 illustrations in colour
- Topics
