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Advances in Experimental Medicine and Biology
cover

Co-signal Molecules in T Cell Activation

Immune Regulation in Health and Disease

Editors: Azuma, Miyuki, Yagita, Hideo (Eds.)

  • Explains the basic concepts and roles of co-signal molecules
  • Discusses applied and clinical studies using co-stimulation mechanisms
  • Presents a variety of potential therapeutic applications
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  • ISBN 978-981-329-717-3
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  • ISBN 978-981-329-716-6
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About this book

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. 

About the authors

Miyuki AzumaTokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, Japan
Hideo YagitaJuntendo University School of Medicine, Dept of Immunology, Japan

Buy this book

eBook n/a
  • ISBN 978-981-329-717-3
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-981-329-716-6
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Co-signal Molecules in T Cell Activation
Book Subtitle
Immune Regulation in Health and Disease
Editors
  • Miyuki Azuma
  • Hideo Yagita
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1189
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-329-717-3
DOI
10.1007/978-981-32-9717-3
Hardcover ISBN
978-981-329-716-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VI, 350
Number of Illustrations
1 b/w illustrations, 21 illustrations in colour
Topics