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Myelin

Basic and Clinical Advances

  • Presents the latest knowledge on the structure and function of myelin in the central and peripheral nervous systems
  • Covers basic neuroscience and clinical neurology viewpoints
  • Shares numerous light and electron microscopy, CT, and MR images

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1190)

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Softcover Book USD 249.99
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  • Dispatched in 3 to 5 business days
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Hardcover Book USD 249.99
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  • Durable hardcover edition
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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xi
  2. Myelination in Neural Development and Regeneration

    1. Front Matter

      Pages 1-1
    2. Cellular Signal-Regulated Schwann Cell Myelination and Remyelination

      • Tomohiro Torii, Yuki Miyamoto, Junji Yamauchi
      Pages 3-22
    3. Activity-Dependent Myelination

      • Daisuke Kato, Hiroaki Wake
      Pages 43-51
    4. Heterogeneity of Oligodendrocytes and Their Precursor Cells

      • Chikako Hayashi, Nobuharu Suzuki
      Pages 53-62
  3. Specialized Structures Along the Myelinated Nerve Fibers

    1. Front Matter

      Pages 63-63
    2. Functional Domains in Myelinated Axons

      • Leonid M. Yermakov, Lulu A. Hong, Domenica E. Drouet, Ryan B. Griggs, Keiichiro Susuki
      Pages 65-83
    3. Mitochondrial Dynamics in Physiology and Pathology of Myelinated Axons

      • Yang Sui, Huy Bang Nguyen, Truc Quynh Thai, Kazuhiro Ikenaka, Nobuhiko Ohno
      Pages 145-163
    4. The Role of Sulfatides in Axon–Glia Interactions

      • Hiroko Baba, Tomoko Ishibashi
      Pages 165-179
    5. Structures and Molecular Composition of Schmidt–Lanterman Incisures

      • Nobuo Terada, Yurika Saitoh, Akio Kamijo, Junji Yamauchi, Nobuhiko Ohno, Takeharu Sakamoto
      Pages 181-198
  4. Myelin Pathology in the Central Nervous System

    1. Front Matter

      Pages 199-199
    2. Multiple Sclerosis

      • Ryo Yamasaki, Jun-ichi Kira
      Pages 217-247

About this book

This book presents the latest exciting advances in understanding of the structure and function of myelin in the central and peripheral nervous systems under normal and pathological conditions. Readers will find state of the art information from the perspectives of both basic neuroscience and clinical neurology and neuropathology. Detailed attention is paid to the findings and implications of recent research on the myelin-forming glial cells such as oligodendrocytes and Schwann cells. The discussion of myelin pathology encompasses a wide range of diseases and conditions, including, for example, multiple sclerosis, Pelizaeus-Merzbacher disease, traumatic brain and spinal cord injuries, brain tumors of glial cell origin, Charcot-Marie-Tooth disease, immune-mediated neuropathy, and diabetic neuropathy. The authors comprise researchers at the cutting edge of biotechnology and experts in the diseases discussed. The clearly written text is supported by numerous high-quality light and electron microscopy, CT, and MR images.

Editors and Affiliations

  • Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Kazunori Sango

  • Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Science, Hachioji, Japan

    Junji Yamauchi

  • Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center, Tokorozawa, Japan

    Toru Ogata

  • Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, USA

    Keiichiro Susuki

About the editors

Kazunori Sango, MD, PhD, Associate Director & Project Leader
Diabetic Neuropathy Project, Department of Sensory and Motor Systems
Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan


Junji Yamauchi, PhD, Associate Professor & Group Leader
Department of Pharmacology, National Research Institute for Child Health and 
Development, Tokyo, Japan


Toru Ogata, MD, PhD, Director
Department of Rehabilitation for the Movement Functions, National 
Rehabilitation Center for Persons with Disabilities, Center for Sport Science and 
Health Promotion, Tokorozawa, Japan


Keiichiro Susuki, MD, PhD, Assistant Professor
Department of Neuroscience, Cell Biology, and Physiology
Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA


Bibliographic Information

  • Book Title: Myelin

  • Book Subtitle: Basic and Clinical Advances

  • Editors: Kazunori Sango, Junji Yamauchi, Toru Ogata, Keiichiro Susuki

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-32-9636-7

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-32-9635-0Published: 06 December 2019

  • Softcover ISBN: 978-981-32-9638-1Published: 19 December 2020

  • eBook ISBN: 978-981-32-9636-7Published: 23 November 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 378

  • Number of Illustrations: 20 b/w illustrations, 48 illustrations in colour

  • Topics: Neurosciences, Neurology, Biochemistry, general

Buy it now

Buying options

eBook USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access