Overview
Highlights different metabolic diseases that are involved in the etiology and progression of pancreatic cancer
Describes the roles of inflammatory pathways in pancreatic cancer cell growth and metastasis, including migration, invasion and angiogenesis
Elucidates the rational targets for diabetes and pancreatic cancer therapy
Reviews the advances in the treatment of pancreatic cancer using immunotherapy and anti-diabetic drugs
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Table of contents (15 chapters)
Keywords
About this book
The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy.
Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.Editors and Affiliations
About the editors
Dr. Aramati BM Reddy is an Assistant Professor at the School of Life Sciences, University of Hyderabad, India. He obtained his Master’s in Biotechnology from SV University, Tirupati-India and Ph.D. from L.V. Prasad Eye Institute, University of Hyderabad, India. He received postdoctoral training at the University of Pennsylvania and University of Texas Medical Branch-Galveston-TX in epigenetics, inflammation, and metabolic disorders. Dr. Reddy’s lab research interests focus on understanding cell signaling and gene regulation in the pathophysiology of metabolic malignancies and glaucoma. His lab is also working on understanding the role of several candidate genes and their significance for the outflow pathway of the aqueous humor of the anterior segment of the eye and glaucoma pathology. He has published 30 research papers in peer-reviewed journals and four book chapters. In addition, he has co-edited three special issues for Hindawi publishers in the field of translational and health sciences. He is a life member for several societies and is currently an executive board member of the Indian society of cell biology.
Bibliographic Information
Book Title: Exploring Pancreatic Metabolism and Malignancy
Editors: Ganji Purnachandra Nagaraju, Aramati BM Reddy
DOI: https://doi.org/10.1007/978-981-32-9393-9
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-32-9392-2Published: 19 December 2019
Softcover ISBN: 978-981-32-9395-3Published: 10 December 2020
eBook ISBN: 978-981-32-9393-9Published: 23 November 2019
Edition Number: 1
Number of Pages: XII, 268
Number of Illustrations: 6 b/w illustrations, 29 illustrations in colour
Topics: Cancer Research, Metabolic Diseases, Human Physiology, Diabetes, Immunology