Authors:
- Nominated as an outstanding Ph.D. thesis by Kyoto University
- Provides novel strategies for the construction of pyrrolocarbazole core structures
- Explains the design and development of divergent synthesis of natural products
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (4 chapters)
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Front Matter
About this book
The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine.
These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.
Authors and Affiliations
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Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Japan
Junpei Matsuoka
About the author
Bibliographic Information
Book Title: Total Synthesis of Indole Alkaloids
Book Subtitle: Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations
Authors: Junpei Matsuoka
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-15-8652-1
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2020
Hardcover ISBN: 978-981-15-8651-4Published: 19 September 2020
Softcover ISBN: 978-981-15-8654-5Published: 20 September 2021
eBook ISBN: 978-981-15-8652-1Published: 18 September 2020
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XII, 82
Number of Illustrations: 73 b/w illustrations, 4 illustrations in colour
Topics: Organic Chemistry, Catalysis, Inorganic Chemistry, Chemistry/Food Science, general, Medicinal Chemistry, Pharmaceutical Sciences/Technology