Drug Discovery and Development

1. Front Matter

   Pages i-viii

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2. Historical Perspective of Drug Discovery and Development

   • Ramarao Poduri

   Pages 1-10

3. Natural Products: Drug Discovery and Development

   • Inder Pal Singh, Furkan Ahmad, Debanjan Chatterjee, Ruchi Bajpai, Neha Sengar

   Pages 11-65

4. The Concept of Receptor and Molecule Interaction in Drug Discovery and Development

   • Ramarao Poduri, Gowraganahalli Jagadeesh

   Pages 67-102

5. Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges

   • Gaurav Joshi, Manpreet Kaur, Raj Kumar

   Pages 103-124

6. Biased Agonism: Renewing GPCR’s Targetability for the Drug Discovery

   • Ravinder Reddy Gaddam, Ajit Vikram

   Pages 125-136

7. Computer-Aided Drug Design

   • Prasad V. Bharatam

   Pages 137-210

8. Pharmacological Screening: Drug Discovery

   • Kumar V. S. Nemmani

   Pages 211-233

9. Drug Target Identification and Validation

   • Srinivas Gullapalli

   Pages 235-249

10. Genetics and Drug Discovery

    • Aruna Poduri, Amit Khanna

    Pages 251-266

11. Discovery and Development of Stem Cells for Therapeutic Applications

    • Arun H. S. Kumar

    Pages 267-296

12. Pharmacokinetics: Theory and Application in Drug Discovery and Development

    • Pradeep Sharma, Nikunjkumar Patel, Bhagwat Prasad, Manthena V. S. Varma

    Pages 297-355

13. Regulatory Toxicology Testing of Pharmaceuticals

    • Venkatesha Udupa, K. S. Rao

    Pages 357-392

14. Nanomedicine: Implications of Nanotoxicology

    • Mohd Aslam Saifi, Ramarao Poduri, Chandraiah Godugu

    Pages 393-415

15. Clinical Research in Pharmaceutical Drug Development

    • Srinivas Ghatta, Michelle Niewood

    Pages 417-434

16. Pharmacovigilance

    • Pramil Tiwari, Prity Rani Deshwal

    Pages 435-449

17. Regulatory Process for New Drug Approval in India

    • K. Bangarurajan

    Pages 451-463

18. Pharmaceutical Industry, Academia, Regulatory Authorities and End User Collaboration in Successful Drug Discovery and Development

    • Ramarao Poduri

    Pages 465-471

19. Statistics in Pharmacology and Toxicology

    • Mohammad Atiar Rahman, Karl Lin

    Pages 473-522

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing.

Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

• Drug discovery
• Pharmacokinetics
• Pharmacodynamics
• Pharmacovigilance
• Drug screening
• Drug Targets
• Regulatory toxicology
• Pharmacogenetics

• Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India

  Ramarao Poduri

Dr. Ramarao Poduri, M Pharm, PhD, is currently working as Dean of Academic Affairs, Dean of the School of Basic and Applied Sciences, and a Professor at the Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India. Dr. Poduri graduated from the Banaras Hindu University of India and completed his postdoctoral research at the University of Illinois, Chicago and Harvard Medical School, Boston. With more than 40 years of teaching experience, he has worked at various prestigious institutes, including Banaras Hindu University, NIPER, S.A.S. Nagar and the Central University of Punjab. Dr. Poduri has published more than 140 peer-reviewed research papers and received e.g. the ISCB Award for Excellence (2009), Indian Society of Chemists & Biologists Pharma-Bio Award (2009), and IASTAM Dr. K.M. Parikh Award (2018). 

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