A word in response to the corona virus crisis: Your print orders will be fulfilled, even in these challenging times. If you don’t want to wait – have a look at our ebook offers and start reading immediately.

Springer Theses

Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

Authors: Bao, Xiucong

Free Preview
  • Nominated as an outstanding Ph.D. thesis by the University of Hong Kong 
  • Reports on important advances in the study of histone posttranslational modifications (PTMs) 
  • Introduces applications of the CLASPI approach in identifying ‘eraser’ enzymes for histone PTMs 
  • Discusses chemical reporters for protein posttranslational modifications 
  • Unravels the role of histone modifications in the regulation of chromatin structure
see more benefits

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-15-2509-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-15-2508-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases.

Table of contents (5 chapters)

Table of contents (5 chapters)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-15-2509-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-15-2508-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation
Authors
Series Title
Springer Theses
Copyright
2020
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-15-2509-4
DOI
10.1007/978-981-15-2509-4
Hardcover ISBN
978-981-15-2508-7
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVIII, 163
Number of Illustrations
36 b/w illustrations, 96 illustrations in colour
Topics