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Cancer Genetics and Therapeutics

Focus on Phytochemicals

  • Book
  • © 2019

Overview

Authors:
  1. Madhumita Roy

    1. Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, Kolkata, India

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  2. Amitava Datta

    1. Department of Computer Science and Software Engineering, The University of Western Australia, Perth, Australia

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  • Provides a unique overview of both the molecular mechanisms of cancer and the use of phytochemicals in preventing cancer and improving cancer therapy
  • Describes different phytochemicals’ mode of action in cancer therapy
  • Discusses interesting topics like pharmacogenomics as use of phytochemicals as bioenhancers

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Cancer: Types and Hallmarks

    • Madhumita Roy, Amitava Datta
    Pages 1-26

  3. Cancer: Genetics and Important Pathways

    • Madhumita Roy, Amitava Datta
    Pages 27-48

  4. Fundamentals of Phytochemicals

    • Madhumita Roy, Amitava Datta
    Pages 49-81

  5. Drugs and Phytochemicals

    • Madhumita Roy, Amitava Datta
    Pages 83-109

  6. Molecular Mechanisms of Phytochemical Actions in Cancer

    • Madhumita Roy, Amitava Datta
    Pages 111-138

  7. Improvement of Cancer Therapy Using Phytochemicals

    • Madhumita Roy, Amitava Datta
    Pages 139-164

  8. Pharmacogenomics and Phytochemicals

    • Madhumita Roy, Amitava Datta
    Pages 165-186

  9. Phytochemicals as Bioenhancers

    • Madhumita Roy, Amitava Datta
    Pages 187-205

  10. Back Matter

    Pages 207-227
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Keywords

About this book

The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.

Authors and Affiliations

  • Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, Kolkata, India

    Madhumita Roy

  • Department of Computer Science and Software Engineering, The University of Western Australia, Perth, Australia

    Amitava Datta

About the authors

Dr. Madhumita Roy completed her MSc in Physics at Calcutta University. She pursued her PhD studies at the Department of Crystallography and Molecular Biology, Saha Institute of Nuclear Physics, Kolkata and was awarded her PhD by the University of Calcutta in 1994. She is currently the Assistant Director and Head of the Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, Kolkata. Her research focuses on cancer biology, particularly radiation biology, cytogenetics, cell biology, tumour cell apoptosis, cancer chemoprevention and environmental toxicology, including the  arsenic disaster in West Bengal, India, identification of important tumor bio-markers, and chemo-enhancing efficacy of tumor cells by plant-derived molecules towards apoptosis by conventional chemotherapeutic drugs. She has published over 74 research papers in respected international journals and has attended more than 100 conferences and workshops in India andabroad.  She is a life member of several societies, such as the Environment Mutagen Society of India (EMSI), Indian Association for Cancer Research (IACR), Electron Microscope Society of India, Indian Science Congress Association, All India Congress of Cytology & Genetics, and the Society of Nutraceuticals & Chronic Diseases.


Dr. Amitava Datta completed his M.Tech and PhD in Computer Science at the Indian Institute of Technology, Madras. He pursued postdoctoral research at the Max Planck Institute for Computer Science and University of Freiburg, both in Germany. He is currently a professor at the Department of Computer Science and Software Engineering at the University of Western Australia. He was a Visiting Professor at the University of Freiburg and is currently a Visiting Professor at the University of Life Sciences, Warsaw, Poland, and South West University, China.  His scientific interests include computational molecular biology, data mining and parallel and distributed computing, and his computational molecular biology research focuses on RNA structural biology and miRNA gene and target prediction, particularly in relation to cancer biology. He has jointly developed the DotKnot software tool for predicting RNA tertiary structures, including pseudoknots, which is used by researchers worldwide. He has published over 150 research papers in respected international journals and in international conference proceedings.

Bibliographic Information

  • Book Title: Cancer Genetics and Therapeutics

  • Book Subtitle: Focus on Phytochemicals

  • Authors: Madhumita Roy, Amitava Datta

  • DOI: https://doi.org/10.1007/978-981-13-9471-3

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-9470-6Published: 27 September 2019

  • Softcover ISBN: 978-981-13-9473-7Published: 28 September 2020

  • eBook ISBN: 978-981-13-9471-3Published: 16 September 2019

  • Edition Number: 1

  • Number of Pages: XVI, 227

  • Number of Illustrations: 27 b/w illustrations, 20 illustrations in colour

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology, Gene Expression, Diagnostic Radiology

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