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Springer Theses

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes

Authors: Wang, Yinli

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  • Nominated as an outstanding PhD thesis by Kyoto University
  • Provides comprehensive information on N-heterocyclic carbenes
  • Offers practical guidance on the design and optimization of catalytic reaction systems
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eBook $84.99
price for USA in USD (gross)
  • Due: October 19, 2019
  • ISBN 978-981-13-9398-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover $149.99
price for USA in USD
  • ISBN 978-981-13-9397-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In this book, the author focuses on exploring new organocatalytic transformations under operationally simple and environmentally friendly reaction conditions. Two new types of catalytic reactions promoted by N-heterocyclic carbenes (NHCs) are described. The oxa- and azacycle-forming reactions of sulfonylalkynols and sulfonylalkynamides are broadly considered to be a new type of activation mode in NHC chemistry, wherein the bond formation with internal O- and N-nucleophiles occurs at the γ-position of the propargyl sulfones with 1,2-sulfonyl migration. The resulting oxa- and azacycles are core structures in many biologically significant compounds and medicinally important agents. 

In addition, the book develops the chiral NHC-catalyzed kinetic resolution of α-hydroxy carboxylic acid derivatives based on chiral recognition of the substrate–cocatalyst complex. In this carboxylate cocatalyst-assisted chiral acylation, the reaction rate acceleration and selectivity enhancement are interpreted in terms of the reversible complexation of the substrate and carboxylate cocatalyst, which is verified by control experiments and measured using analytical methods. The findings described here reveal a promising new aspect of not only NHC catalysis but also identifying novel catalysis systems. 

Table of contents (4 chapters)

Table of contents (4 chapters)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • Due: October 19, 2019
  • ISBN 978-981-13-9398-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover $149.99
price for USA in USD
  • ISBN 978-981-13-9397-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes
Authors
Series Title
Springer Theses
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-9398-3
DOI
10.1007/978-981-13-9398-3
Hardcover ISBN
978-981-13-9397-6
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVI, 105
Topics