Overview
Focuses on the clinical relevance of epigenetic changes at a time when epigenetics is beginning to make its way into clinical diagnostics
Includes boxes for defining key concepts and terminology, clinical cases of diseases,methodological details, as well as, intuitive subheadings to navigate each chapter and quickly locate information
Provides a detailed and practical description of the challenges and barriers that must be overcome to obtain medical quality diagnostic results from epigenetic testing
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Table of contents (11 chapters)
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Front Matter
Keywords
About this book
In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories.
The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
Editors and Affiliations
About the editors
Associate Professor Luke B. Hesson is a Clinical Scientist who has studied the genetic and epigenetic causes of cancer for more than 18 years. He holds a doctorate in Clinical Genetics from The University of Birmingham UK and is a former Director for the Australian Society for Medical Research (2012-2015). In 2016 he was admitted as a Fellow of the Faculty of Science of the Royal College of Pathologists of Australasia. He has lectured at the University of New South Wales, Sydney in genetics, epigenetics, cancer, pathology and personalised medicine. Luke is currently the Head of Cancer Diagnostics and Laboratory Director at the Garvan Institute of Medical Research DNA sequencing facility in Sydney, which provides clinically accredited genome sequencing.
Dr. Antonia L. Pritchard is currently a Senior Lecturer at the University of the Highlands and Islands, Scotland, UK and a visiting scientist at QIMR Berghofer Medical Research Institute, Brisbane, Australia. She gained her Ph.D in Psychiatric Genetics from the University of Birmingham in 2005. Her research interests have centred around the genetic influence on disease (including Alzheimer’s disease, asthma and cancer) and on the human immune system. Dr Pritchard has published over 60 peer reviewed articles on these themes and continues to work on the interaction of genetics, genomics and immunology in cancer, particularly focused on melanoma. She is a member of the British Society of Immunology (BSI), the American Association for Cancer Research (AACR), the Association of Cancer Immuotherapy (CIMT) and the Society for Melanoma Research (SMR). Dr Pritchard’s research group is a member of the GenoMEL Consortium and the BAP1 Interest Group (BIG) Consortium, both of which are highly productive, collaborative and multidisciplinary groups which comprise researchers from across the World.
Bibliographic Information
Book Title: Clinical Epigenetics
Editors: Luke B. Hesson, Antonia L. Pritchard
DOI: https://doi.org/10.1007/978-981-13-8958-0
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-8957-3Published: 25 September 2019
Softcover ISBN: 978-981-13-8960-3Published: 25 September 2020
eBook ISBN: 978-981-13-8958-0Published: 31 August 2019
Edition Number: 1
Number of Pages: XI, 265
Number of Illustrations: 26 b/w illustrations, 8 illustrations in colour
Topics: Gene Expression, Gene Function, Gene Therapy, Cytogenetics, Molecular Medicine