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Advances in Experimental Medicine and Biology

Protein Allostery in Drug Discovery

Editors: Zhang, Jian, Nussinov, Ruth (Eds.)

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  • Focuses on protein allostery in drug discovery
  • Draws together the study of protein structure/function and the study of allostery
  • Contributed by experts in this field
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-981-13-8719-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-981-13-8718-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. 


About the authors

Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA

Table of contents (15 chapters)

Table of contents (15 chapters)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-981-13-8719-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-981-13-8718-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein Allostery in Drug Discovery
Editors
  • Jian Zhang
  • Ruth Nussinov
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1163
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-8719-7
DOI
10.1007/978-981-13-8719-7
Hardcover ISBN
978-981-13-8718-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 384
Number of Illustrations
21 b/w illustrations, 82 illustrations in colour
Topics