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Zebrafish: A Model for Marine Peptide Based Drug Screening

Authors: Ramachandran, Saravanan, Rajagopal, Senthilkumar

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  • Presents the cutting-edge use of zebrafish as a model organism for screening the efficacy of various marine peptides/toxins
  • Discusses the potential of various marine peptides/toxins as anti-cancer and cardioprotective agents
  • Evaluates the teratogenic activity of marine peptides on zebrafish embryos
  • Offers up-to-date information on marine pharmacognosy
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-981-13-7844-7
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-981-13-7843-0
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  • Usually dispatched within 3 to 5 business days.
About this book

This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.

About the authors

Dr. Saravanan Ramachandran is an Assistant Professor of Marine Pharmacology at the Faculty of Allied Health Sciences, Chettinad University Chennai, India. He completed his PhD in Marine Biotechnology at Annamalai University, India. His research interests focus on drugs from marine organisms. He has received two research awards from the Indian Council of Medical Research and the Centre for Marine Living Resources and Ecology, Kochi, India, and he has published 40 research articles in international/national journals. He is a member of Society for Biotechnologists (India), International Neurotoxin Association, holds 2 patents and 1 copyright and has submitted 15 gene sequences to the NCBI. Currently, he is serving as the principal investigator of a research project funded by the Govterment of India Department of Biotechnology. 

Dr. Senthilkumar Rajagopal is an Assistant Professor at the Department of Biochemistry, School of Life Sciences at Rayalaseema University, Kurnool, India. He completed his PhD in Biochemistry at Annamalai University, India, and his postdoctoral fellowship at various Universities in the USA, including the University of Virginia, Harvard and Virginia Commonwealth University. Dr. Rajagopal is a recipient of the Rameshwardasji Birla Smarak Kosh Endowment award from Mumbai Medical Trust, and the Ramalingaswami Re-entry Fellowship from the Department of Biotechnology, Ministry of Science and Technology, Government of India. His research has addressed protein kinase C modulation of calcium channels currents, and was the principal investigator of a major project entitled “G-protein coupled receptor mediated intracellular mechanisms by alcohol-induced digestive disorders in the gastrointestinal tract”. Other interests include G-protein coupled receptor signaling pathways in smooth muscle physiology and neurotransmitters transporters to central nervous system. Dr. Rajagopal is a life member of a number of respected scientific associations, such as the Indian Society for Atherosclerosis Research (ISAR), The Indian Science Congress Association (ISCA), Society for Free Radical Research India (SFRR), The Indian Society of Cell Biology (ISCB), the American Association of Pharmaceutical Scientists (AAPS) and the Science Advisory Board (SAB), USA.

Table of contents (5 chapters)

Table of contents (5 chapters)
  • Biomedical Importance of Marine Peptides/Toxins

    Pages 1-14

    Ramachandran, Saravanan (et al.)

  • Teratogenic Activity of Peptides in Zebrafish Model

    Pages 15-25

    Ramachandran, Saravanan (et al.)

  • Teratogenic Activity of Toxins in Zebrafish Model

    Pages 27-42

    Ramachandran, Saravanan (et al.)

  • Anticancer Properties of Marine Peptides/Toxins Using Zebrafish Model

    Pages 43-53

    Ramachandran, Saravanan (et al.)

  • Protective Effect of Marine Peptides/Toxins in CVD Using Zebrafish Model

    Pages 55-73

    Ramachandran, Saravanan (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-981-13-7844-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-981-13-7843-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Zebrafish: A Model for Marine Peptide Based Drug Screening
Authors
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-7844-7
DOI
10.1007/978-981-13-7844-7
Hardcover ISBN
978-981-13-7843-0
Edition Number
1
Number of Pages
XI, 73
Number of Illustrations
10 b/w illustrations, 29 illustrations in colour
Topics