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Advances in Experimental Medicine and Biology

Therapeutic Enzymes: Function and Clinical Implications

Editors: Labrou, Nikolaos (Ed.)

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  • Incorporates a wealth of research that clarifies several aspects of the development and application of therapeutic enzymes
  • Equips readers with a comprehensive understanding of enzyme-based therapeutic molecules
  • Emphasizes three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-981-13-7709-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-13-7708-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Production and Purification of Therapeutic Enzymes

    Pages 1-24

    Taipa, M. Ângela (et al.)

  • Production of Therapeutic Enzymes by Lentivirus Transgenesis

    Pages 25-54

    Rodríguez, María Celeste (et al.)

  • Quality Control and Downstream Processing of Therapeutic Enzymes

    Pages 55-80

    Gervais, David

  • X-Ray Crystallography in Structure-Function Characterization of Therapeutic Enzymes

    Pages 81-103

    Papageorgiou, Anastassios C.

  • Application of Fluorescence in Studying Therapeutic Enzymes

    Pages 105-114

    Wang, Zhaoshuai (et al.)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-981-13-7709-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-13-7708-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Therapeutic Enzymes: Function and Clinical Implications
Editors
  • Nikolaos Labrou
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1148
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-7709-9
DOI
10.1007/978-981-13-7709-9
Hardcover ISBN
978-981-13-7708-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 386
Number of Illustrations
19 b/w illustrations, 71 illustrations in colour
Topics