Actin Polymerization in Apicomplexan

A Structural, Functional and Evolutionary Analysis

Editors: Kale, Avinash (Ed.)

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  • Reviews the mechanism of gliding motility in apicomplexan organisms
  • Discusses the structural, evolutionary, and functional role of actin-regulatory proteins
  • Introduces a mathematical model to help understand the role of actin-regulatory proteins in motility
  • Explores the potential of actin and its regulatory proteins as potential drug targets against apicomplexan organisms
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  • ISBN 978-981-13-7450-0
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Hardcover $159.99
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About this book

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.

The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria.  As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.

Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics. 

About the authors

Dr. Avinash Kale is a Reader at the School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences, Mumbai, India. His research interests are in the area of integrative structure biology and proteomics (ISBAP). He has more than 16 years of teaching experience in computational biology, biotechnology, molecular modeling and drug design, group theory, spectroscopy, and bioinformatics. He has served as a reviewer for a number of international journals, including the Journal of Biomolecular Structure and Dynamics (USA), and Nature Scientific Reports (USA).

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-13-7450-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-13-7449-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Actin Polymerization in Apicomplexan
Book Subtitle
A Structural, Functional and Evolutionary Analysis
Editors
  • Avinash Kale
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-7450-0
DOI
10.1007/978-981-13-7450-0
Hardcover ISBN
978-981-13-7449-4
Edition Number
1
Number of Pages
XI, 101
Number of Illustrations
11 illustrations in colour
Topics