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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

The Shape of Organic Synthesis to Come

  • Book
  • © 2019

Overview

Editors:
  1. Yuichi Kobayashi

    1. Department of Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

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  • Presents a quick survey of topics in organic synthesis for top researchers, young chemists, graduate students, and those looking for new research based on organic chemistry
  • Suggests future research based on organic synthesis
  • Enables understanding of the purpose and major results of the contents with schemes and illustrations

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xxv
    Download chapter PDF

  2. Microbial Fraction Library: A Screening Source for Drug Discovery

    • Toshihiko Nogawa, Julius Adam V. Lopez, Hiroyuki Osada
    Pages 1-20

  3. Efficient Total Synthesis of Ōmura Natural Products

    • Toshiaki Sunazuka, Tomoyasu Hirose, Satoshi Ōmura
    Pages 21-47

  4. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products FR182877 and Taxol

    • Masahisa Nakada
    Pages 49-73

  5. Synthetic Approaches on the Pluramycin-Class Antibiotics

    • Yoshio Ando, Kei Kitamura, Takashi Matsumoto, Keisuke Suzuki
    Pages 75-100

  6. Recent Progress on the Total Synthesis of Duocarmycins A and SA, Yatakemycin, and PDE-I and PDE-II

    • Juri Sakata, Hidetoshi Tokuyama
    Pages 101-124

  7. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis

    • Tohru Oishi
    Pages 125-143

  8. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications

    • Yuichi Kobayashi, Miwa Shimoda
    Pages 145-169

  9. Total Synthesis of Ingenol

    • Tyler F. Higgins, Jeffrey D. Winkler
    Pages 171-192

  10. Strategies for the Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids

    • Yuichi Kobayashi, Masao Morita
    Pages 193-231

  11. Biosynthesis, Biological Functions, and Receptors of Leukotriene B4 and 12(S)-Hydroxyheptadecatrienoic Acid

    • Toshiaki Okuno, Takehiko Yokomizo
    Pages 233-246

  12. Synthesis of Classical/Nonclassical Hybrid Cannabinoids and Related Compounds

    • Thanh C. Ho, Marcus A. Tius
    Pages 247-289

  13. Exploring Bioactive Marine Natural Products and Identification of Their Molecular Targets

    • Masayoshi Arai
    Pages 291-303

  14. Target Protein Chemical Modification

    • Hiroyuki Nakamura
    Pages 305-333

  15. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes

    • Suguru Yoshida, Takamitsu Hosoya
    Pages 335-355
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Keywords

About this book

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.


Editors and Affiliations

  • Department of Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

    Yuichi Kobayashi

About the editor

Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology. 

Bibliographic Information

  • Book Title: Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

  • Book Subtitle: The Shape of Organic Synthesis to Come

  • Editors: Yuichi Kobayashi

  • DOI: https://doi.org/10.1007/978-981-13-6244-6

  • Publisher: Springer Singapore

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-6243-9Published: 14 June 2019

  • Softcover ISBN: 978-981-13-6246-0Published: 15 August 2020

  • eBook ISBN: 978-981-13-6244-6Published: 30 May 2019

  • Edition Number: 1

  • Number of Pages: XXV, 355

  • Number of Illustrations: 279 b/w illustrations, 127 illustrations in colour

  • Topics: Organic Chemistry, Medicinal Chemistry, Pharmacy

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