Advances in Experimental Medicine and Biology

Antimicrobial Peptides

Basics for Clinical Application

Editors: Matsuzaki, Katsumi (Ed.)

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  • Presents the latest findings on antimicrobial peptides
  • Elucidates their mechanisms of antimicrobial action
  • Examines AMP activities beyond antimicrobial action
  • Discusses the progress made, and obstacles to, their clinical application
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About this book

This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

About the authors

Katsumi Matsuzaki is a Professor at the Graduate School of Pharmaceutical Sciences, Kyoto University, where he also completed his PhD in Biophysical Chemistry. Dr. Matsuzaki has authored more than 100 publications, which have been cited more than 10000 times. In addition to serving as an editor for Biochimica et Biophysica Acta-Biomembranes, Journal of Peptide Science, and European Biophysics Journal, he is a member of the Biophysical Society (USA), The Pharmaceutical Society Japan, The Japanese Peptide Society, and The Biophysical Society of Japan. He was awarded The Japanese Peptide Society Award for Young Scientists, The Pharmaceutical Society Japan Award for Young Scientists, and the Erwin von Bälz Prize. His primary research interest is in membrane biophysics, including peptide–membrane interactions and in-cell biophysics.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Antimicrobial Peptides of Multicellular Organisms: My Perspective

    Pages 3-6

    Zasloff, Michael

  • Membrane Permeabilization Mechanisms

    Pages 9-16

    Matsuzaki, Katsumi

  • Elementary Processes and Mechanisms of Interactions of Antimicrobial Peptides with Membranes—Single Giant Unilamellar Vesicle Studies—

    Pages 17-32

    Hasan, Moynul (et al.)

  • The Mechanisms of Action of Cationic Antimicrobial Peptides Refined by Novel Concepts from Biophysical Investigations

    Pages 33-64

    Aisenbrey, Christopher (et al.)

  • Anionic Lipid Clustering Model

    Pages 65-71

    Epand, Richard M.

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-981-13-3588-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-981-13-3587-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Antimicrobial Peptides
Book Subtitle
Basics for Clinical Application
Editors
  • Katsumi Matsuzaki
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1117
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-3588-4
DOI
10.1007/978-981-13-3588-4
Hardcover ISBN
978-981-13-3587-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 304
Number of Illustrations
18 b/w illustrations, 55 illustrations in colour
Topics