JSS Research Series in Statistics

Survival Analysis with Correlated Endpoints

Joint Frailty-Copula Models

Authors: Emura, Takeshi, Matsui, Shigeyuki, Rondeau, Virginie

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  • The first-ever book tailored to the problem of correlated endpoints in survival analysis
  • Offers a clearly structured textbook on survival analysis, suitable for graduate students, (bio)statisticians, mathematicians, and medical researchers alike
  • Helps readers apply the statistical methods of this book to real data, by means of the R package
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eBook $44.99
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  • ISBN 978-981-13-3516-7
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Softcover $59.99
price for USA in USD
About this book

This book introduces readers to advanced statistical methods for analyzing survival data involving correlated endpoints. In particular, it describes statistical methods for applying Cox regression to two correlated endpoints by accounting for dependence between the endpoints with the aid of copulas. The practical advantages of employing copula-based models in medical research are explained on the basis of case studies.

In addition, the book focuses on clustered survival data, especially data arising from meta-analysis and multicenter analysis. Consequently, the statistical approaches presented here employ a frailty term for heterogeneity modeling. This brings the joint frailty-copula model, which incorporates a frailty term and a copula, into a statistical model. The book also discusses advanced techniques for dealing with high-dimensional gene expressions and developing personalized dynamic prediction tools under the joint frailty-copula model.

To help readers apply the statistical methods to real-world data, the book provides case studies using the authors’ original R software package (freely available in CRAN). The emphasis is on clinical survival data, involving time-to-tumor progression and overall survival, collected on cancer patients. Hence, the book offers an essential reference guide for medical statisticians and provides researchers with advanced, innovative statistical tools. The book also provides a concise introduction to basic multivariate survival models.

About the authors

Takeshi Emura, Chang Gung University

Shigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine 
Virginie Rondeau, INSERM U 1219

Reviews

“This book can be used as a textbook for a course aimed at postgraduate students in biostatistics and medicine.” (Denis Sidorov, zbMATH 1429.62003, 2020)

Table of contents (6 chapters)

Table of contents (6 chapters)

Buy this book

eBook $44.99
price for USA in USD
  • ISBN 978-981-13-3516-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Softcover $59.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Survival Analysis with Correlated Endpoints
Book Subtitle
Joint Frailty-Copula Models
Authors
Series Title
JSS Research Series in Statistics
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-3516-7
DOI
10.1007/978-981-13-3516-7
Softcover ISBN
978-981-13-3515-0
Series ISSN
2364-0057
Edition Number
1
Number of Pages
XVII, 118
Number of Illustrations
10 b/w illustrations, 19 illustrations in colour
Topics