Biochemical and Biophysical Roles of Cell Surface Molecules

1. Front Matter

   Pages i-xi

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2. Membrane Organization

   1. Front Matter

      Pages 1-1

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   2. Status of Membrane Asymmetry in Erythrocytes: Role of Spectrin

      • Sauvik Sarkar, Dipayan Bose, Rajendra P. Giri, Mrinmay K. Mukhopadhyay, Abhijit Chakrabarti

      Pages 3-11

   3. Multiple Roles, Multiple Adaptors: Dynein During Cell Cycle

      • Devashish Dwivedi, Mahak Sharma

      Pages 13-30

   4. Changes in the Nuclear Envelope in Laminopathies

      • Subarna Dutta, Maitree Bhattacharyya, Kaushik Sengupta

      Pages 31-38

3. Biophysics of Membrane Proteins and Cell Surface Macromolecules

   1. Front Matter

      Pages 39-39

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   2. The Effect of Nanoparticles on the Cluster Size Distributions of Activated EGFR Measured with Photobleaching Image Correlation Spectroscopy

      • Chiara Paviolo, James W. M. Chon, Andrew H. A. Clayton

      Pages 41-52

   3. Factors Influencing the Chaperone-Like Activity of Major Proteins of Mammalian Seminal Plasma, Equine HSP-1/2 and Bovine PDC-109: Effect of Membrane Binding, pH and Ionic Strength

      • Cheppali Sudheer Kumar, Bhanu Pratap Singh, Sk. Alim, Musti J. Swamy

      Pages 53-68

   4. Exploring the Mechanism of Viral Peptide-Induced Membrane Fusion

      • Gourab Prasad Pattnaik, Geetanjali Meher, Hirak Chakraborty

      Pages 69-78

   5. Amyloids Are Novel Cell-Adhesive Matrices

      • Reeba S. Jacob, Subhadeep Das, Namrata Singh, Komal Patel, Debalina Datta, Shamik Sen et al.

      Pages 79-97

   6. The Prospects of Cadherin-23 as a Mediator of Homophilic Cell-Cell Adhesion

      • Malay Kumar Sannigrahi, Sai Srinivas, Sabyasachi Rakshit

      Pages 99-105

   7. Structural-Mechanical and Biochemical Functions of Classical Cadherins at Cellular Junctions: A Review and Some Hypotheses

      • Prince Tiwari, Arpita Mrigwani, Harpreet Kaur, Pallavi Kaila, Rajendra Kumar, Purnananda Guptasarma

      Pages 107-138

4. G-Protein Coupled Receptors: From Structure to Function

   1. Front Matter

      Pages 139-139

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   2. Identification of Sphingolipid-binding Motif in G Protein-coupled Receptors

      • Sandeep Shrivastava, Md. Jafurulla, Shrish Tiwari, Amitabha Chattopadhyay

      Pages 141-149

   3. Molecular Signatures of Cholesterol Interaction with Serotonin Receptors

      • Madhura Mohole, Xavier Prasanna, Durba Sengupta, Amitabha Chattopadhyay

      Pages 151-160

5. Cell Surface Macromolecules in Neurobiology

   1. Front Matter

      Pages 161-161

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   2. Group I Metabotropic Glutamate Receptors (mGluRs): Ins and Outs

      • Prabhat Kumar Mahato, Namrata Ramsakha, Prachi Ojha, Ravinder Gulia, Rohan Sharma, Samarjit Bhattacharyya

      Pages 163-175

   3. Soluble Amyloid Precursor Protein α: Friend or Foe?

      • Nicola J. Corbett, Nigel M. Hooper

      Pages 177-183

   4. C. elegans Locomotion: Finding Balance in Imbalance

      • Shruti Thapliyal, Kavita Babu

      Pages 185-196

6. Cell Surface Macromolecules: Infection, Immunity and Disease

   1. Front Matter

      Pages 197-197

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Cell surface small molecules and macromolecules, such as members of cholesterol family (including steroid hormones), the glycolipid family (sphingolipids), the glycoprotein family (both N-linked and O-linked), and a vast array of other receptors have been shown to be involved in normal and abnormal cellular processes. The 11^th International Symposium on Cell Surface Macromolecules, held in Mohali, India, in February 2017 provided a comprehensive update on the major advances in this area.

Presenting selected contributions from this meeting, this book comprises 24 chapters, which provide in-depth analyses of data on the role of cell surface macromolecules in cellular function and their alterations associated with pathological conditions. It includes comprehensive research papers and critical overviews of the functional role of cell surface molecules, discussing topics such as biochemical, biophysical, and cell biological approaches to study cell membrane molecules, and metabolism of glycoconjugates.

• Cell Membrane
• Cell Surface Receptors
• Cholesterol
• Glycolipids
• Glycoprotein

• Centre for Protein Science, Design and Engineering, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, India

  Kausik Chattopadhyay

• Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, USA

  Subhash C. Basu

Dr. Kausik Chattopadhyay is an Associate Professor in the Department of Biological Sciences at the Indian Institute of Science Education and Research Mohali (IISER Mohali). He received his PhD degree in Biochemistry from the Calcutta University in 2004, and subsequently completed his post-doctoral research with Prof. Stanley G. Nathenson at the Department of Microbiology and Immunology at the Albert Einstein College of Medicine, Bronx, New York, USA. He joined IISER Mohali as an Assistant Professor in 2009, and became Associate Professor in 2014. His research interests focus on understanding the structure-function mechanisms of membrane-damaging, bacterial, pore-forming toxins, and their implications for the host-pathogen interaction processes and immunity. He received the prestigious National BioScience Award for Career Development for the year 2014, awarded by the Department of Biotechnology, Ministry of Science & Technology, Government of India for his work in this area.

 

Dr. Subhash C. Basu is an Emeritus Professor at the University of Notre Dame (UND), Department of Chemistry and Biochemistry and also the president of the CDDRF (Cancer Drug Delivery Research Foundation). He received his PhD degree in Biochemistry in 1966 from the University of Michigan and was a Helen Hay Whitney Research Fellow (1966-70) under Professor Saul Roseman at the Johns Hopkins University. He joined both the teaching and research faculty at the UND in 1970 and became a Full Professor and Chairman of the Biochemistry, Biophysics and Molecular Biology program in 1983. He was awarded a D.Sc. degree in Biochemistry from the University of Calcutta, India in 1976 . He received the Jacob Javits Neuroscience Research Award from NIH (1989-98), and the S. C. Roy Medal of Achievement Award   from the University of Calcutta, India in 1990. He was elected to the prestigious Johns Hopkins Honor Society in 1995. He has been an elected fellowof the American Association for the Advancement of Sciences (FAAAS) since 1988. He received the “NRI-2015 Award” Trophy in the International Professional category from the respected India Times newspaper in April 2015.

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