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Advances in Experimental Medicine and Biology

Integrative Structural Biology with Hybrid Methods

Editors: Nakamura, H., Kleywegt, G., Burley, S., Markley, J.L. (Eds.)

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  • Presents impact of the integrative structural biology
  • Provides Future perspective of the hybrid methods and their applications
  • Covers detailed description of experimental and computational methods in the hybrid methods
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-13-2200-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-13-2199-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested in this book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.

About the authors

Haruki Nakamura

Osaka University, Institute for Protein Research, Japan

Gerard J. Kleywegt

European Bioinformat Inst, Prot Data Bank Europe, England

Stephen K. Burley

Rutgers State University, Center for Integrative Proteomics Research, USA

John L. Markley 

University of Wisconsin, Biochemistry Department, Natl Magnet Resonance Facil Madison, USA

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Overall Introduction and Rationale, with View from Computational Biology

    Nakamura, Haruki

    Pages 3-9

  • Integrative/Hybrid Methods Structural Biology: Role of Macromolecular Crystallography

    Burley, Stephen K.

    Pages 11-18

  • View from Nuclear Magnetic Resonance Spectroscopy

    Markley, John L.

    Pages 19-22

  • Complementary Use of Electron Cryomicroscopy and X-Ray Crystallography: Structural Studies of Actin and Actomyosin Filaments

    Fujii, Takashi (et al.)

    Pages 25-42

  • Current Solution NMR Techniques for Structure-Function Studies of Proteins and RNA Molecules

    Markley, John L.

    Pages 43-58

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-13-2200-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-13-2199-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Integrative Structural Biology with Hybrid Methods
Editors
  • Haruki Nakamura
  • Gerard Kleywegt
  • Stephen Burley
  • John L. Markley
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1105
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-2200-6
DOI
10.1007/978-981-13-2200-6
Hardcover ISBN
978-981-13-2199-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VI, 272
Number of Illustrations
17 b/w illustrations, 44 illustrations in colour
Topics