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Advances in Experimental Medicine and Biology

Neurotoxicity of Aluminum

Editors: Niu, Qiao (Ed.)

  • reviewing the cutting-edge research development linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease
  • focusing on aluminum levels in brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta
  • highlighting detailed mechanisms of aluminum in oxidative stress and cell death, especially about apoptosis and necroptosis
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Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-981-13-1370-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-981-13-1369-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity. 

About the authors

Dr. Qiao Niu is a professor and director of the Department of Occupational Health, School of Public Health, Shanxi Medical University. He is also director of the Institute of Preventive Medicine at the same university. Dr. Niu is executive director of the Chinese Society for Toxicology, and of the Labor Health and Occupational Disease Branch of the Chinese Preventive Medicine Association. His research focuses on neurotoxicology, an area in which he has published more than 100 research articles.

Table of contents (10 chapters)

  • Overview of the Relationship Between Aluminum Exposure and Health of Human Being

    Niu, Qiao

    Pages 1-31

  • The Chemistry of Human Exposure to Aluminium

    Exley, Christopher

    Pages 33-37

  • Entry and Deposit of Aluminum in the Brain

    Wang, Linping

    Pages 39-51

  • Aluminum as a CNS and Immune System Toxin Across the Life Span

    Shaw, Christopher A.

    Pages 53-83

  • Occupational Exposure to Aluminum and Cognitive Impairment

    Lu, Xiaoting

    Pages 85-97

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-981-13-1370-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-981-13-1369-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neurotoxicity of Aluminum
Editors
  • Qiao Niu
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1091
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-1370-7
DOI
10.1007/978-981-13-1370-7
Hardcover ISBN
978-981-13-1369-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VII, 191
Number of Illustrations and Tables
12 b/w illustrations, 13 illustrations in colour
Topics