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Advances in Experimental Medicine and Biology

Chromosome Translocation

Editors: Zhang, Yu (Ed.)

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  • Introduces mechanisms and methodologies of chromosome translocations 
  • Provides a clear overview of the basics 
  • Reviews up-to-date knowledge of chromosome translocations 
  • Contributions from experts in the field
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  • ISBN 978-981-13-0593-1
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About this book

This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases.

The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation.

It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.

About the authors

Dr. Yu Zhang is Assistant Investigator at National Institute of Biological Sciences, Beijing, China.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Historical and Clinical Perspectives on Chromosomal Translocations

    Pages 1-14

    Wilch, Ellen S. (et al.)

  • Induction of Chromosomal Translocations with CRISPR-Cas9 and Other Nucleases: Understanding the Repair Mechanisms That Give Rise to Translocations

    Pages 15-25

    Brunet, Erika (et al.)

  • Dynamics of Double-Strand Breaks: Implications for the Formation of Chromosome Translocations

    Pages 27-38

    Gothe, Henrike Johanna (et al.)

  • The CRISPR/Cas9 System as a Tool to Engineer Chromosomal Translocation In Vivo

    Pages 39-48

    Cheong, Taek-Chin (et al.)

  • Generation of Genomic Alteration from Cytidine Deamination

    Pages 49-64

    Liu, Xiaojing (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-981-13-0593-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-13-0592-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $159.99
price for USA in USD
  • ISBN 978-981-13-4459-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chromosome Translocation
Editors
  • Yu Zhang
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1044
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-0593-1
DOI
10.1007/978-981-13-0593-1
Hardcover ISBN
978-981-13-0592-4
Softcover ISBN
978-981-13-4459-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
V, 168
Number of Illustrations
2 b/w illustrations, 27 illustrations in colour
Topics

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