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  • © 2018

Gene and Cell Therapy: Biology and Applications

  • Limited literature is available in an evolving field of translational medicine
  • A special chapter on clinical applications of stem cells of hematopoeitic origin written by clinicians
  • Basic and special topics covered comprehensively that appeals to the graduates and advanced researchers

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xv
  2. Gene Therapy

    1. Front Matter

      Pages 1-1
    2. Retroviral Vectors in Gene Therapy

      • Chitra Gopinath, Trupti Job Nathar, Everette Jacob Remington Nelson
      Pages 3-28
    3. Adeno-associated Virus Vectors in Gene Therapy

      • Bertin Mary, Nusrat Khan, Sathyathithan Arumugam, Himanshi Saxena, Mohit Kumar, Paramasivam Manimaran et al.
      Pages 29-56
    4. Nanointerventions for Gene Therapy

      • K. Uma Maheswari, Vadim Annenkov
      Pages 57-110
    5. Viral- and Non-viral-Based Hybrid Vectors for Gene Therapy

      • Manohar Mahato, Giridhara R. Jayandharan, Praveen Kumar Vemula
      Pages 111-130
    6. Pharmaco-Gene Therapy

      • Martin H. M. Sailer, Ganesh Ram Sahu, Arkasubhra Ghosh
      Pages 131-145
    7. Aptamer as Therapeutics for Cancer with Focus on Retinoblastoma

      • Nithya Subramanian, Akilandeswari Balachandran, Krishnakumar Subramanian
      Pages 147-194
  3. Cell Therapy – “With Emphasis on Gene Modified Cell Therapies”

    1. Front Matter

      Pages 195-195
    2. Haploidentical Stem Cell Transplantation

      • Narendra Agrawal, Dinesh Bhurani
      Pages 291-305

About this book

Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail.  Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.


Editors and Affiliations

  • Department of BSBE, IIT-Kanpur, Kanpur, India

    Giridhara R. Jayandharan

About the editor

Dr. Giridhara R. Jayandharan is currently working as an Associate Professor at Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India. Dr. Jayandharan completed his PhD from Christian Medical College, Vellore, India in the year 2006 and subsequently worked as post-doctoral fellow at University of Florida, Gainesville, USA between the year 2007-2009 where he worked extensively on Gene Therapy. Before joining the coveted Indian Institute of Technology, he worked as a faculty member in the Department of Hematology and also at Center for Stem Cell Research, Christian Medical College, Vellore, India. His main area of research includes Gene transfer and therapy, Human molecular genetics and Virology.

Dr. Jayandharan is a prolific publisher as he has over 60 papers in peer reviewed high quality journals. He is recipient of several awards and honors. Most notable awards received by him are; Wellcome Trust DBT senior fellowship, Swarnajayanthi fellowship from Department of Science and Technology, Government of India, Young scientist award, YIM Boston, USA; Senior Innovative Young Biotechnologist award, Department of Biotechnology, Government of India; Bayer Hemophilia Early Career Investigator Award, Bayer Inc, USA etc.

Dr. Jayandharan is a member of several notable academies/societies such as International Society for Thrombosis and Hemostasis, European Society for Gene and Cell Therapy, American Society for Gene and Cellular Therapy. 

Bibliographic Information

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access