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Focus on Structural Biology

Molecular Dynamics Analyses of Prion Protein Structures

The Resistance to Prion Diseases Down Under

Authors: Zhang, Jiapu

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  • Systemically studies all the structures of PrPs and associations 
  •  
  • Introduces the reproducible Molecular Dynamics, QM/MM, Optimization skills into the studies
  • The 1011 color photos lead you are fast and reliable to know PrPs
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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-981-10-8815-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-10-8814-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-981-13-4247-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.

Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.

Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.   

This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

Table of contents (16 chapters)

Table of contents (16 chapters)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-981-10-8815-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-10-8814-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-981-13-4247-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Dynamics Analyses of Prion Protein Structures
Book Subtitle
The Resistance to Prion Diseases Down Under
Authors
Series Title
Focus on Structural Biology
Series Volume
10
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-8815-5
DOI
10.1007/978-981-10-8815-5
Hardcover ISBN
978-981-10-8814-8
Softcover ISBN
978-981-13-4247-9
Series ISSN
1571-4853
Edition Number
1
Number of Pages
XXIX, 375
Number of Illustrations
318 b/w illustrations, 278 illustrations in colour
Topics