Overview
- Systemically studies all the structures of PrPs and associations
- Introduces the reproducible Molecular Dynamics, QM/MM, Optimization skills into the studies
- The 1011 color photos lead you are fast and reliable to know PrPs
Part of the book series: Focus on Structural Biology (FOSB, volume 10)
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Table of contents (16 chapters)
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Front Matter
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Part III
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Front Matter
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Part IV
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Front Matter
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Part V
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Front Matter
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Keywords
About this book
Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.
Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.
Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.
This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Authors and Affiliations
Bibliographic Information
Book Title: Molecular Dynamics Analyses of Prion Protein Structures
Book Subtitle: The Resistance to Prion Diseases Down Under
Authors: Jiapu Zhang
Series Title: Focus on Structural Biology
DOI: https://doi.org/10.1007/978-981-10-8815-5
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-10-8814-8Published: 07 August 2018
Softcover ISBN: 978-981-13-4247-9Published: 23 December 2018
eBook ISBN: 978-981-10-8815-5Published: 20 July 2018
Series ISSN: 1571-4853
Series E-ISSN: 2542-9566
Edition Number: 1
Number of Pages: XXIX, 375
Number of Illustrations: 318 b/w illustrations, 278 illustrations in colour
Topics: Proteomics