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Springer Theses

Molecular Recognition of DNA Double Helix

Gene Regulation and Photochemistry of BrU Substituted DNA

Authors: Saha, Abhijit

  • Nominated by Kyoto University as an outstanding Ph.D. thesis
  • Benefits readers as the design and synthesis of small molecules as articifial transcriptional activators is explained
  • Motivates readers to use this method as a detection tool for other small molecules by conjugating a pyrene-type electron with rich moiety
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-981-10-8746-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-981-10-8745-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book. 

About the authors

Dr. Abhijit SAHAInstitut Curie, Campus Universitaire, Orsay, France 

Table of contents (6 chapters)

  • Overview of DNA Minor Groove-Binding Synthetic Small Molecules and Photochemistry of BrU-Substituted DNA

    Saha, Dr. Abhijit

    Pages 1-29

  • Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity

    Saha, Dr. Abhijit

    Pages 31-48

  • Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy Against Pluripotency Genes in Mouse Fibroblast

    Saha, Dr. Abhijit

    Pages 49-63

  • Development of a Novel Photochemical Detection Technique for the Analysis of Polyamide-Binding Sites

    Saha, Dr. Abhijit

    Pages 65-80

  • Examining Cooperative Binding of Sox2 on DC5 Regulatory Element Upon Complex Formation with Pax6 Through Excess Electron Transfer Assay

    Saha, Dr. Abhijit

    Pages 81-100

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-981-10-8746-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-981-10-8745-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Recognition of DNA Double Helix
Book Subtitle
Gene Regulation and Photochemistry of BrU Substituted DNA
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-8746-2
DOI
10.1007/978-981-10-8746-2
Hardcover ISBN
978-981-10-8745-5
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVI, 114
Number of Illustrations and Tables
8 b/w illustrations, 50 illustrations in colour
Topics