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Springer Theses

Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

Authors: Wong, Yuan Qiang Daniel

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  • Winner of the Wang Gungwu Award for the best PhD thesis in the Natural Sciences by the National University of Singapore (2016)
  • Summarizes the pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics
  • Addresses a significant paradigm shift from the conventional approach of directly targeting cancer
  • Explores a rich and largely unexplored domain for platinum-based drug design for superior immuno-chemotherapeutics
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  • ISBN 978-981-10-8594-9
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Hardcover $149.99
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Softcover $149.99
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About this book

This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.

About the authors

Daniel Wong was born in Singapore and graduated with honors from the National University of Singapore (NUS) in 2011. Encouraged by a positive undergraduate research experience, he then continued to complete his doctoral studies in NUS in 2015 under the guidance of Prof. Ang Wee Han, working mainly on the immuno-modulating effects of platinum agents for cancer therapy. In 2015, he joined Nanyang Technological University as a Research Fellow under the supervision of Prof. Par Nordlund, a renowned structural biologist. There, he employed structure-based drug design techniques against molecular targets in both immuno-oncology and malaria. At the same time, he is also experimenting with new progressive methodologies for simultaneous target and ligand discovery. Apart from research, Daniel likes mentoring students because of their infectious enthusiasm and he believes that the future rests upon them. Daniel is a recipient of the Wang Gungwu Medal (2016) for best PhD thesis in the Natural Sciences in NUS and the Springer Thesis Prize (2017).

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Introduction

    Pages 1-31

    Wong, Daniel Yuan Qiang

  • Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum(IV) Prodrugs

    Pages 33-53

    Wong, Daniel Yuan Qiang

  • Probing the Platinum(IV) Prodrug Hypothesis. Are Platinum(IV) Complexes Really Prodrugs of Cisplatin?

    Pages 55-71

    Wong, Daniel Yuan Qiang

  • Induction of Targeted Necrosis with HER2-Targeted Platinum(IV) Anticancer Prodrugs

    Pages 73-101

    Wong, Daniel Yuan Qiang

  • Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents

    Pages 103-130

    Wong, Daniel Yuan Qiang

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-981-10-8594-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
Softcover $149.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-8594-9
DOI
10.1007/978-981-10-8594-9
Hardcover ISBN
978-981-10-8593-2
Softcover ISBN
978-981-13-4194-6
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXX, 147
Number of Illustrations
42 b/w illustrations, 47 illustrations in colour
Topics