Multiscale Mechanobiology in Tissue Engineering

1. Front Matter

   Pages i-xiii

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2. A Review of Bioreactors and Mechanical Stimuli

   • Marzia Brunelli, Cécile Perrault, Damien Lacroix

   Pages 1-22

3. Multiscale Simulation of Bioreactor Design and In Vitro Conditions

   • Adrien Baldit, Marzia Brunelli, Ana Campos Marin, Damien Lacroix

   Pages 23-36

4. Mechanical Stimulation in a PCL Additive Manufacturing Scaffold

   • Marzia Brunelli, Cécile Perrault, Damien Lacroix

   Pages 37-57

5. Towards a New Approach to Analyse Quality Control and Morphometric Variability in a Scaffold

   • Ana Campos Marin, Damien Lacroix

   Pages 59-80

6. Computational Simulation of Cell Seeding in a Tissue Engineering Scaffold

   • Ana Campos Marin, Damien Lacroix

   Pages 81-104

7. Collagen Gel Cell Encapsulation to Study Mechanotransduction

   • Maryam Shariatzadeh, Adrien Baldit, Cécile Perrault, Damien Lacroix

   Pages 105-125

8. Collagen Gel Cell Encapsulation to Study the Effect of Fluid Flow on Mechanotransduction

   • Maryam Shariatzadeh, Cécile Perrault, Damien Lacroix

   Pages 127-142

9. Computational Modelling of Collagen Hydrogel

   • Andre Castro, Maryam Shariatzadeh, Damien Lacroix

   Pages 143-158

10. Mechanical Load Transfer at the Cellular Level

    • Sara Barreto, Damien Lacroix

    Pages 159-179

11. Quantification of CSK Mechanics and Deformation in Relation to Cellular Functioning

    • Sara Barreto, Damien Lacroix

    Pages 181-193

12. The Future of Tissue Engineering Design for Bioreactor Stimulation

    • Damien Lacroix

    Pages 195-199

13. Back Matter

    Pages 201-203

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This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

• Tissue engineering
• Computational simulations
• Multiscale approach
• Bioreactor design
• Cell mechanics

• INSIGNEO Institute for in silico Medicine, The University of Sheffield, Sheffield, United Kingdom

  Damien Lacroix, Marzia Brunelli, Cécile Perrault, Adrien Baldit, Maryam Shariatzadeh, Ana Campos Marin, Andre Castro, Sara Barreto

Damien Lacroix, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Marzia Brunelli, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Cecile Perrault, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Adrien Baldit, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Maryam Shariatzadeh, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Ana Campos Marin, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Andre Castro, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK
Sara Barreto, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK

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