Genomics-Driven Healthcare

1. Front Matter

   Pages i-xv

   PDF

2. Rethinking Drug Discovery and Targeting After the Genomic Revolution

   • Dharmesh R. Chejara, Ravindra V. Badhe, Pradeep Kumar, Yahya E. Choonara, Lomas K. Tomar, Charu Tyagi et al.

   Pages 1-17

3. Living Between Sickness and Health: Where Is the Human Genome Leading Us?

   • Amy Broadwater, Yashwant Pathak

   Pages 19-36

4. Pharmacogenomics: Setting Newer Paradigms of Genetics in Therapy and Medicine

   • Sanjay Dey, Kumud Joshi, Bhaskar Mazumder

   Pages 37-58

5. Bioinformatics and Pharmacogenomics: Tools to Understand and Accelerate Infectious Disease Control

   • Ashwani Sharma, Subrata Sinha, Surabhi Johari, Bhaskar Mazumder

   Pages 59-69

6. Race and Ethnicity: Understanding Difference in the Genome Era

   • Shannon Kelly, Yashwant Pathak

   Pages 71-87

7. The Food Metabolome and Novel Dietary Biomarkers Associated with Diseases

   • Orhan E. Arslan, Philip Palmon

   Pages 89-107

8. Impact of Genomics on Drug Discovery and Clinical Medicine

   • Deepak Gupta

   Pages 109-131

9. Genomics and Drug Transporters and Application in Drug Discovery, Delivery, and Development

   • Robert Gharavi, Hazem E. Hassan

   Pages 133-175

10. Genomics and Drug-Metabolizing Enzymes and Its Application in Drug Delivery: Evaluating the Influence of the Microbiome

    • Sheeba Varghese Gupta

    Pages 177-200

11. Essentials of Genomics in the Continuum of Translational Research

    • Sadaf Aslam

    Pages 201-214

12. Charting a Course for Genomic Medicine from Base Pair to Bedside

    • Teresa Vo

    Pages 215-225

13. Pharmacogenomics and Pharmacoepigenomics: Impact on Therapeutic Strategies

    • Kristopher R. Hall, Tamer E. Fandy

    Pages 227-238

14. Clinical Pharmacogenomics and Personalized Medicine: New Strategies to Maximize Drug Efficacy and Avoid Adverse Drug Reaction

    • Chonlaphat Sukasem, Sadeep Medhasi

    Pages 239-261

15. Epigenetic Patterns/Therapies Associated with Genetic Disorders

    • Elizabeth Mazzio, Karam F. A. Soliman

    Pages 263-279

16. Neurodegenerative Disease Conditions and Genomic Treatment for Better Health

    • Ravindra V. Badhe, Dharmesh R. Chejara, Pradeep Kumar, Yahya E. Choonara, Viness Pillay

    Pages 281-310

17. Recent Trends in -Omics-Based Methods and Techniques for Lung Disease Prevention

    • Raisah Salhab, Yashwant Pathak

    Pages 311-329

18. Impact of Genomics on Personalization of Breast Cancer Care

    • F. Scott Heinemann, Alice Police, Erin Lin, Mandy Liu, Sherry Liang, Ying Huang

    Pages 331-372

19. Pharmacogenomics: A New Approach for Preventing Severe Cutaneous Adverse Drug Reactions

    • Chonlaphat Sukasem, Therdpong Tempark

    Pages 373-409

This book evaluates trends arising in “-Omics” sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology.

Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.

• Drug delivery
• Drug discovery
• Drug metabolism
• Drug transporters
• Functional genomics
• Genomics-based rational therapeutics
• Nanotherapy
• Omics-driven pharmaceuticals
• Pharmacogenetics
• Pharmacogenomics
• SNPs

“This is an update on the current understanding of pharmacogenomics, drug targets, and drug transporters. … This book appears to be written for practitioners and provides clinically relevant information that can be used in practice. … One of the unique aspects of this book is the focus on the implications of pharmacogenomics with respect to disease prevention, not merely treatment.” (Nicole Sifontis, Doody's Book Reviews, November, 2018)

• University of South Florida Health College of Pharmacy, Tampa, USA

  Yashwant Pathak

Dr Yashwant Pathak is the Associate Dean for Faculty Affairs and Full Professor in the College of Pharmacy, Morsani College of Medicine and College of Public Health at the University of South Florida (USF). He is an internationally recognized scholar, researcher and educator in the areas of health care education, nanotechnology, drug delivery systems and nutraceuticals.

Dr Pathak was awarded his MPharm and PhD from Nagpur University, India. He also holds an Executive MBA and Masters in Conflict Management from Sullivan University, Louisville, USA. His post-doctoral training was at Royal free Hospital London, UK, Hebrew University of Jerusalem, Israel and University of Michigan Medical Center at Ann Arbor, Michigan, USA.

In addition to his primary roles, Dr Pathak is also Professor at  USF College of Social and Behavioral Sciences and USF College of Sustainability; Adjunct Professor at JSS University Mysore, India; holds adjunct appointments at the University of West Indies Arthur Lok Jack Graduate School of Business, Trinidad And Tobago, and the College of Business at USF for DBA programs; and is a member of the Advisory Board for NERC (Nanotechnology Education and Research Centre) College of Engineering, USF. Prior to these current appointments, he gained 9 years of experience as Dean at USF and 17 years as faculty and researcher. He has also worked as Chair of the International Working group for USF Health and Director of the Nano Center.

Dr Pathak has over 150 research publications and over 22 edited books. He has presented his work in more than 100 national and international conferences. In the last two years he has been awarded the Fulbright Senior Scholar Core Fellowship Award 2015-2016 for Indonesia; the Endeavour Executive fellowship by Australian Government 2015 in collaboration with Deakin University; the CNPQ Brazil Government Fellowship; the Outstanding Achievement Award for Global Engagement by USF; the Outstanding faculty Award for USF March 2017; and been made a Fellow of NSF I-Corps USF 2016.

Policies and ethics