Happy Holidays—Our $30 Gift Card just for you, and books ship free! Shop now>>

Advances in Experimental Medicine and Biology

DNA Replication

From Old Principles to New Discoveries

Editors: Masai, Hisao, Foiani, Marco (Eds.)

Free Preview
  • Presents a historical overview of eukaryotic DNA replication by one of the legendary scientists in the field
  • Reviews comprehensive compilation of the newest information on DNA replication
  • Approaches issues related to DNA replication from various points of view
  • Emphasizes the latest results on mechanistic and structural aspects of DNA replication
  • Features the most recent development on the genome-wide view of where and when DNA replication starts and stops, and how those profiles are correlated with other genomic signatures
  • Provides a novel concept for the highly adaptive and plastic mode of eukaryotic DNA replication
see more benefits

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-981-10-6955-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-10-6954-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-981-13-4972-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

About the authors

Hisao Masai, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Marco Foiani, IFOM,  Instituto FIRC di Oncologia Molecolare, Milan, Italy

Reviews

“This text provides impressively comprehensive coverage of the important topics and current questions in DNA replication. It will be best suited for readers with strong backgrounds in molecular biology. … Recommended. Graduate students, researchers, faculty, and professionals.” (M. S. Kainz, Choice, Vol. 56 (1), September, 2018)

Table of contents (23 chapters)

Table of contents (23 chapters)
  • Historical Perspective of Eukaryotic DNA Replication

    Pages 1-41

    Kelly, Thomas

  • Regulation of Replication Origins

    Pages 43-59

    Marks, Anna B. (et al.)

  • Molecular Mechanism for Chromatin Regulation During MCM Loading in Mammalian Cells

    Pages 61-78

    Sugimoto, Nozomi (et al.)

  • Initiation of DNA Replication at the Chromosomal Origin of E. coli, oriC

    Pages 79-98

    Katayama, Tsutomu

  • Initiation of DNA Replication in the Archaea

    Pages 99-115

    Bell, Stephen D.

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-981-10-6955-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-10-6954-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-981-13-4972-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
DNA Replication
Book Subtitle
From Old Principles to New Discoveries
Editors
  • Hisao Masai
  • Marco Foiani
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1042
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-6955-0
DOI
10.1007/978-981-10-6955-0
Hardcover ISBN
978-981-10-6954-3
Softcover ISBN
978-981-13-4972-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 581
Number of Illustrations
7 b/w illustrations, 87 illustrations in colour
Topics