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Springer Theses

Investigations of Cellular and Molecular Biophysical Properties by Atomic Force Microscopy Nanorobotics

Authors: Li, Mi

  • Awarded as an Outstanding PhD thesis by the Chinese Academy of Sciences in 2015
  • Describes a comprehensive study on using atomic force microscopy (AFM) to investigate single-cell and single-molecule activities
  • Explores the biomedical applications of atomic force microscopy (AFM) in clinical practice for targeted cancer therapy
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eBook $89.00
price for USA in USD (gross)
  • ISBN 978-981-10-6829-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.99
price for USA in USD
  • ISBN 978-981-10-6828-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book presents methodological and application research in detecting cellular and molecular biophysical properties based on atomic force microscopy (AFM) nanorobotics. Series methods for in situ label-free visualizing and quantifying the multiple physical properties of single cells and single molecules were developed, including immobilization strategies for observing fine structures of living cells, measurements of single-cell mechanics, force recognition of molecular interactions, and mapping protein organizations on cell surface. The biomedical applications of these methods in clinical lymphoma treatments were explored in detail, including primary sample preparation, cancer cell recognition, AFM detection and data analysis. Future directions about the biomedical applications of AFM are also given.

About the authors

Dr. Mi Li received his B.E. and M.E. degree from Huazhong University of Science and Technology, Wuhan, China in 2006 and 2008, respectively, and Ph. D. degree from Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China in 2015. Currently Dr. Li is Associate Professor at the Shenyang Institute of Automation and his research areas include micro/nano automation technology, atomic force microscopy, nanorobot and cell mechanics. He has published more than 30 articles in academic journals as first author, and received Outstanding Doctoral Dissertation Award of Chinese Academy of Sciences in 2016. 

Table of contents (7 chapters)

  • Introduction to Atomic Force Microscopy-Based Nanorobotics for Biomedical Applications

    Li, Mi

    Pages 1-20

  • Immobilization Methods for Observing Living Mammalian Suspended Cells by AFM

    Li, Mi

    Pages 21-31

  • Measuring the Mechanical Properties of Single Cells by AFM

    Li, Mi

    Pages 33-47

  • Single-Molecule Recognition and Force Measurements by AFM

    Li, Mi

    Pages 49-64

  • Mapping Membrane Proteins on Cell Surface by AFM

    Li, Mi

    Pages 65-77

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-981-10-6829-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.99
price for USA in USD
  • ISBN 978-981-10-6828-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Investigations of Cellular and Molecular Biophysical Properties by Atomic Force Microscopy Nanorobotics
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-6829-4
DOI
10.1007/978-981-10-6829-4
Hardcover ISBN
978-981-10-6828-7
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIII, 135
Number of Illustrations
75 b/w illustrations
Topics