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Role of Transcription Factors in Gastrointestinal Malignancies

Editors: Nagaraju, Ganji Purnachandra, Pallaval Veera Bramhachari (Eds.)

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  • This book highlights different transcription factors that are involved in gastro-intestinal cancers
  • It describes the roles of transcription factors in tumor growth and tumor cell metastasis including migration, invasion and angiogenesis
  • This book also elucidates the rational targets for gastro-intestinal cancers therapy
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eBook $189.00
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  • ISBN 978-981-10-6728-0
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Hardcover $249.99
price for USA in USD
  • ISBN 978-981-10-6727-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
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  • ISBN 978-981-13-3893-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

About the authors

Dr. Nagaraju GP is a faculty member at the Department of Hematology and Medical Oncology, Emory University School of Medicine. He completed his MS and his Ph.D., both in biotechnology, at Sri Venkateswara University, India. His research chiefly focuses on translational projects related to gastrointestinal malignancies. He has published over 60 research articles in highly reputed international journals and has presented more than 50 abstracts at various national and International conferences. He has also served as an editorial board member of several internationally recognized academic journals. He is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He is a member of the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, the RNA Society and the American Association of Cancer Research (AACR).

Dr. Bramhachari PV is presently a member of Faculty and Head of the Department of Biotechnology at Krishna University, India. His current research work largely focuses on basic and translational cancer research. He completed his Ph.D. at Goa University, India and began his professional career as a postdoctoral scientist at the Indian Institute of Science, Bangalore, before working at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research in Brisbane, Australia. He has published more than 60 research articles in several prestigious peer-reviewed journals and presented 40 abstracts at various national and international conferences. He has successfully completed two major research projects, is a member of various prestigious scientific societies, and has served as an editorial board member and reviewer for several peer-reviewed international journals. As a leading researcher in the field of cancer biology, he is currently investigating the role of various transcriptional factors in the identification of novel cancer therapies for GI cancers.

Table of contents (39 chapters)

Table of contents (39 chapters)
  • Transcription Factors in Gastrointestinal Malignancies

    Pages 1-3

    Bramhachari, Pallaval Veera (et al.)

  • YY1 and KLF4: Their Role in Gastrointestinal Malignancies

    Pages 5-17

    Tillu, Himanshu (et al.)

  • AP-1: Its Role in Gastrointestinal Malignancies

    Pages 19-32

    Sushma, P. S. (et al.)

  • Overview of Transcription Factors in Esophagus Cancer

    Pages 33-44

    Bramhachari, Pallaval Veera (et al.)

  • NF-κB Role and Potential Drug Targets in Gastrointestinal Cancer

    Pages 45-71

    Bhukya, Prudhvi Lal (et al.)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-981-10-6728-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-981-10-6727-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-981-13-3893-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Role of Transcription Factors in Gastrointestinal Malignancies
Editors
  • Ganji Purnachandra Nagaraju
  • Pallaval Veera Bramhachari
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd
eBook ISBN
978-981-10-6728-0
DOI
10.1007/978-981-10-6728-0
Hardcover ISBN
978-981-10-6727-3
Softcover ISBN
978-981-13-3893-9
Edition Number
1
Number of Pages
IX, 517
Number of Illustrations
16 b/w illustrations, 64 illustrations in colour
Topics