- Introduces the basic information of mtDNA
- Summarize the latest development of mtDNA and disease
- Focus on mtDNA biology and the roles of mtDNA in disease
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- About this book
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The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.
- About the authors
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Dr. Hongzhi Sun is Professor and President of Jinzhou Hospital, Jinzhou Medical University, Jinzhou, Liaoning Province, China.
Dr. Xiangdong Wang is Distinguished Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.
- Table of contents (15 chapters)
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How Far Can Mitochondrial DNA Drive the Disease?
Pages 1-8
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Mitochondrial DNA in Lung Cancer
Pages 9-22
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Approach, Application, and Bioethics of mtDNA Sequencing in Cancer
Pages 23-38
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Roles of Mitochondrial DNA Signaling in Immune Responses
Pages 39-53
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Mitochondrial DNA in Telocytes
Pages 55-70
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Table of contents (15 chapters)
- Download Sample pages 2 PDF (672.4 KB)
- Download Table of contents PDF (113.8 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Mitochondrial DNA and Diseases
- Editors
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- Hongzhi Sun
- Xiangdong Wang
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 1038
- Copyright
- 2017
- Publisher
- Springer Singapore
- Copyright Holder
- Springer Nature Singapore Pte Ltd.
- eBook ISBN
- 978-981-10-6674-0
- DOI
- 10.1007/978-981-10-6674-0
- Hardcover ISBN
- 978-981-10-6673-3
- Softcover ISBN
- 978-981-13-4929-4
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- VII, 230
- Number of Illustrations
- 27 b/w illustrations, 62 illustrations in colour
- Topics
