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Advances in Experimental Medicine and Biology

DJ-1/PARK7 Protein

Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases

Editors: Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M. M. (Eds.)

  • Covers various oxidative stress-related diseases, including cancer, neurodegenerative diseases, and type 2 diabetes as well as male infertility
  • Broadens the understanding of the various uses of DJ-1 such as a biomarker for diagnosis of neurodegenerative diseases
  • Enriches understanding of DJ-1-binding compounds which are promising drugs for various oxidative stress-related diseases
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Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-981-10-6583-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-981-10-6582-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. 

About the authors

Hiroyoshi Ariga
Faculty of Pharmaceutical Sciences, Hokkaido University
Sapporo, Japan

Sanae M.M. Iguchi‐Ariga
Faculty of Agriculture, Hokkaido UniversitySapporo,Japan

Table of contents (13 chapters)

  • Introduction/Overview

    Ariga, Hiroyoshi (et al.)

    Pages 1-4

  • Structural Biology of the DJ-1 Superfamily

    Smith, Nathan (et al.)

    Pages 5-24

  • Expression of DJ-1 in Neurodegenerative Disorders

    Antipova, Daria (et al.)

    Pages 25-43

  • Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance

    Kawate, Takahiko (et al.)

    Pages 45-59

  • Role of DJ-1 in Fertilization

    Chunna, An (et al.)

    Pages 61-66

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-981-10-6583-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-981-10-6582-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
DJ-1/PARK7 Protein
Book Subtitle
Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases
Editors
  • Hiroyoshi Ariga
  • Sanae M. M. Iguchi-Ariga
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1037
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-6583-5
DOI
10.1007/978-981-10-6583-5
Hardcover ISBN
978-981-10-6582-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 222
Number of Illustrations and Tables
32 b/w illustrations, 46 illustrations in colour
Topics