Advances in Experimental Medicine and Biology

Developmental Origins of Health and Disease (DOHaD)

From Biological Basis to Clinical Significance

Editors: Kubota, Takeo, Fukuoka, Hideoki (Eds.)

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  • Covers numerous diseases associated with DOHaD
  • Presents an update of our understanding of molecular mechanisms for DOHaD
  • Based on the latest biological data
  • Suggests importance of early interventions for adult diseases
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-10-5526-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-10-5525-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

About the authors

Takeo Kubota

Faculty of Child Studies, Seitoku University, Chiba, Japan


Hideoki Fukuoka

Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Table of contents (9 chapters)

Table of contents (9 chapters)
  • One-Carbon Metabolism and Lipid Metabolism in DOHaD

    Fukuoka, Hideoki (et al.)

    Pages 3-9

  • Novel Models of Epigenetic Gene Regulation in the Nutritional Environment

    Mochizuki, Kazuki (et al.)

    Pages 11-18

  • Epigenetic Switching and Neonatal Nutritional Environment

    Hashimoto, Koshi (et al.)

    Pages 19-25

  • Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)

    Itoh, Hiroaki (et al.)

    Pages 29-39

  • Fetal Origins of Hypertension

    Arima, Yuichiro (et al.)

    Pages 41-48

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-981-10-5526-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-981-10-5525-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Developmental Origins of Health and Disease (DOHaD)
Book Subtitle
From Biological Basis to Clinical Significance
Editors
  • Takeo Kubota
  • Hideoki Fukuoka
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1012
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-5526-3
DOI
10.1007/978-981-10-5526-3
Hardcover ISBN
978-981-10-5525-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VII, 95
Number of Illustrations
7 b/w illustrations, 16 illustrations in colour
Topics