Happy holidays from us to you—get up to $30 off your next print or eBook! Shop now >>

Advances in Experimental Medicine and Biology

Organelle Contact Sites

From Molecular Mechanism to Disease

Editors: Tagaya, Mitsuo, Simmen, Thomas (Eds.)

  • Provides a comprehensive description of organelle contact sites (MCS)
  • Assembles the full array of research about the organization and roles of MCS
  • Presents extensive evidence of the significance of MCS for various human diseases
see more benefits

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-981-10-4567-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-981-10-4566-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases.

MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders,  and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases.  Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come.

This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.

About the authors

Mitsuo Tagaya received his Ph.D. at Osaka University in 1985 by revealing the catalytic mechanisms of glycogen phosphorylase and glycogen synthase. He developed new affinity labeling reagents comprising pyridoxal phosphate for the identification of nucleotide-binding sites. He then worked with James E. Rothman, a Nobel Prize laureate in Physiology or Medicine 2013, at Princeton, where he began organelle research. After returning to Japan, he became associate professor in a newly established department, the School of Life Sciences, at Tokyo University of Pharmacy and Life Sciences in 1994, and became professor in 1997. His interest has focused on the mechanism of the organization of the microdomains of the endoplasmic reticulum.

Thomas Simmen studied biochemistry at the University of Basel. Following a Ph.D. in Lausanne, where he unraveled the functions of the AP-4 adaptor complex in basolateral sorting, he did two postdoctoral fellowships, one with Roberto Sitia in Milan, the other with Gary Thomas in Portland OR. This period introduced him to the connections between the endoplasmic reticulum (ER) and mitochondria, because he worked on Ero1α, a regulator of ER-mitochondria calcium signaling, and on PACS-2, the first identified factor required for the tethering of the ER to mitochondria. Starting in 2005, Thomas Simmen became a faculty member of the Department of Cell Biology at the University of Alberta (Edmonton, Canada). The Simmen laboratory detected ER protein-folding enzymes such as calnexin and TMX1 and the small GTPase Rab32 as factors controlling the function of ER-mitochondria contacts and the mitochondria-associated membrane (MAM).

Table of contents (17 chapters)

  • Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research

    Simmen, Thomas (et al.)

    Pages 1-12

  • Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs)

    Herrera-Cruz, Maria Sol (et al.)

    Pages 13-31

  • Regulation of Mitochondrial Dynamics and Autophagy by the Mitochondria-Associated Membrane

    Tagaya, Mitsuo (et al.)

    Pages 33-47

  • Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs)

    Marchi, Saverio (et al.)

    Pages 49-67

  • Ceramide Transport from the Endoplasmic Reticulum to the Trans Golgi Region at Organelle Membrane Contact Sites

    Hanada, Kentaro

    Pages 69-81

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-981-10-4567-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-981-10-4566-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Organelle Contact Sites
Book Subtitle
From Molecular Mechanism to Disease
Editors
  • Mitsuo Tagaya
  • Thomas Simmen
Series Title
Advances in Experimental Medicine and Biology
Series Volume
997
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-4567-7
DOI
10.1007/978-981-10-4567-7
Hardcover ISBN
978-981-10-4566-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 257
Number of Illustrations
1 b/w illustrations, 42 illustrations in colour
Topics